Chiral Phosphinoaryldihydrooxazoles as Ligands in Asymmetric Catalysis: Pd‐Catalyzed Allylic Substitution

Enantioselectivities up to 99% ee and excellent yields under mild reaction conditions could be realized in allylic alkylations [Eq. (a)] with palladium catalysts prepared with the chiral ligands 1. Enantiomerically pure phosphinoaryldihydrooxazoles (1) are readily accessible from commercially available chiral amino alcohols. HNu = H2C(COOMe)2, H2C(COMe)2, HC(NHAc)(COOEt)2.