Pathological evaluation of colorectal cancer specimens: advanced and early lesions.

医学 粘膜下层 瘤芽 结直肠癌 淋巴血管侵犯 淋巴结 病态的 癌症 切除缘 腺癌 放射科 肿瘤科 病理 转移 外科 内科学 淋巴结转移 切除术
作者
Annika Resch,Nora Schneider,Cord Langner
出处
期刊:PubMed 卷期号:51 (1): 12-22 被引量:4
链接
标识
摘要

Surgical resection is the treatment of choice for patients with locally confined disease, but early cancers may be adequately treated by endoscopic resection alone. In advanced colorectal cancers, accurate staging including pathological lymph node assessment is crucial for patient counselling and decision making. In addition to the extent of surgical lymph node removal and the thoroughness of the pathologist in dissecting the cancer specimen lymph node recovery is related to the actual number of regional lymph nodes that is related to patient demographics, tumor location and biology. Current guidelines recommend a minimum of twelve nodes harvested as the standard of care. In patients with node-negative tumors a variety of histological features may be used for adjusted risk assessment, including histological subtyping, lymphatic and venous invasion, tumor budding and tumor necrosis as well as the anti-tumor host inflammatory response which has been identified as favorable feature in several studies. In rectal cancer, involvement of the circumferential resection margin and the plane of surgery are important prognostic factors. Early or superficial colorectal cancer is defined as invasive adenocarcinoma invading into, but not beyond the submucosa. A number of features require special attention because they are used to determine the necessity for radical surgery. In addition to the assessment of completeness of excision, these include the recording of parameters that predict the presence of lymph node metastasis, namely the depth of invasion into the submucosa, tumor grade, and the presence of additional risk factors, such as angioinvasion and tumor budding. The combination of these parameters allows the stratification of affected individuals into low-risk and high-risk categories.

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
bias发布了新的文献求助10
1秒前
小马甲应助忧虑的无血采纳,获得10
2秒前
默默完成签到,获得积分10
2秒前
ping发布了新的文献求助10
2秒前
fei发布了新的文献求助10
2秒前
许净发布了新的文献求助10
3秒前
3秒前
3秒前
nki发布了新的文献求助10
4秒前
阿廖莎发布了新的文献求助10
4秒前
4秒前
Rita发布了新的文献求助10
5秒前
SYLH应助冰释采纳,获得30
5秒前
hh发布了新的文献求助10
5秒前
6秒前
老默发布了新的文献求助10
7秒前
谢123完成签到 ,获得积分10
7秒前
Rzozsye发布了新的文献求助10
9秒前
ghy完成签到 ,获得积分10
9秒前
麦芽发布了新的文献求助10
9秒前
累啊发布了新的文献求助10
10秒前
orixero应助fei采纳,获得10
11秒前
11秒前
坦率的枕头完成签到,获得积分10
12秒前
12秒前
12秒前
早日毕业佳完成签到,获得积分10
13秒前
九九完成签到,获得积分10
13秒前
14秒前
大模型应助安安采纳,获得10
15秒前
灵巧一笑完成签到 ,获得积分20
15秒前
风趣安青发布了新的文献求助10
15秒前
NexusExplorer应助dream采纳,获得10
15秒前
landiao发布了新的文献求助10
16秒前
123发布了新的文献求助10
17秒前
量子星尘发布了新的文献求助10
19秒前
20秒前
21秒前
22秒前
852应助风趣安青采纳,获得10
22秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 700
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
Indomethacinのヒトにおける経皮吸収 400
Effective Learning and Mental Wellbeing 400
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3975900
求助须知:如何正确求助?哪些是违规求助? 3520207
关于积分的说明 11201602
捐赠科研通 3256663
什么是DOI,文献DOI怎么找? 1798403
邀请新用户注册赠送积分活动 877564
科研通“疑难数据库(出版商)”最低求助积分说明 806430