生物
线粒体融合
细胞生物学
线粒体
线粒体生物发生
生物能学
生物发生
细胞命运测定
线粒体分裂
细胞代谢
细胞
线粒体DNA
遗传学
基因
转录因子
作者
Emilie Schrepfer,Luca Scorrano
出处
期刊:Molecular Cell
[Elsevier]
日期:2016-03-01
卷期号:61 (5): 683-694
被引量:426
标识
DOI:10.1016/j.molcel.2016.02.022
摘要
Mitochondrial architecture is involved in several functions crucial for cell viability, proliferation, senescence, and signaling. In particular, mitochondrial dynamics, through the balance between fusion and fission events, represents a central mechanism for bioenergetic adaptation to metabolic needs of the cell. As key regulators of mitochondrial dynamics, the fusogenic mitofusins have recently been linked to mitochondrial biogenesis and respiratory functions, impacting on cell fate and organism homeostasis. Here we review the implication of mitofusins in the regulation of mitochondrial metabolism, and their consequence on energy homeostasis at the cellular and physiological level, highlighting their crucial role in metabolic disorders, cancer, and aging.
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