mTORC1型
自噬相关蛋白13
自噬
细胞生物学
P70-S6激酶1
ULK1
袋3
核糖体s6激酶
激酶
蛋白激酶A
生物
化学
生物化学
丝裂原活化蛋白激酶激酶
PI3K/AKT/mTOR通路
信号转导
安普克
细胞凋亡
出处
期刊:Science Signaling
[American Association for the Advancement of Science (AAAS)]
日期:2009-08-18
卷期号:2 (84)
被引量:201
标识
DOI:10.1126/scisignal.284pe51
摘要
High nutrient availability stimulates the mammalian target of rapamycin complex 1 (mTORC1) to coordinately activate anabolic processes, such as protein synthesis, while inhibiting the cellular catabolism of autophagy. Positive regulation of protein synthesis through the mTORC1 substrates p70 ribosomal S6 kinase (p70S6K) and eukaryotic initiation factor 4E binding protein 1 (4E-BP1) has been well characterized. The complementary inhibitory mechanism in which mTORC1 phosphorylates the autophagy regulatory complex containing unc-51-like kinase 1 (ULK1), the mammalian Atg13 protein, and focal adhesion kinase interacting protein of 200 kD (FIP200) has also been elucidated.
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