Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial

医学 心肌梗塞 多不饱和脂肪酸 维生素E 内科学 维生素 心脏病学 随机对照试验 脂肪酸 生物化学 生物 抗氧化剂
作者
Roberto Marchioli
出处
期刊:The Lancet [Elsevier BV]
卷期号:354 (9177): 447-455 被引量:3802
标识
DOI:10.1016/s0140-6736(99)07072-5
摘要

Summary Background There is conflicting evidence on the benefits of foods rich in vitamin E (α-tocopherol), n-3 polyunsaturated fatty acids (PUFA), and their pharmacological substitutes. We investigated the effects of these substances as supplements in patients who had myocardial infarction. Methods From October, 1993, to September, 1995, 11 324 patients surviving recent (≤3 months) myocardial infarction were randomly assigned supplements of n-3 PUFA (1 g daily, n=2836), vitamin E (300 mg daily, n=2830), both (n=2830), or none (control, n=2828) for 3·5 years. The primary combined efficacy endpoint was death, non-fatal myocardial infarction, and stroke. Intention-to-treat analyses were done according to a factorial design (two-way) and by treatment group (four-way). Findings Treatment with n-3 PUFA, but not vitamin E, significantly lowered the risk of the primary endpoint (relativerisk decrease 10% [95% CI 1–18] by two-way analysis, 15% [2–26] by four-way analysis). Benefit was attributable to a decrease in the risk of death (14% [3–24] two-way, 20% [6–33] four-way) and cardiovascular death (17% [3–29] two-way, 30% [13–44] four-way). The effect of the combined treatment was similar to that for n-3 PUFA for the primary endpoint (14% [1–26]) and for fatal events (20% [5–33]). Interpretation Dietary supplementation with n-3 PUFA led to a clinically important and satistically significant benefit. Vitamin E had no benefit. Its effects on fatal cardiovascular events require further exploration.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
chx123发布了新的文献求助10
1秒前
小奶发布了新的文献求助10
1秒前
大力水香发布了新的文献求助10
2秒前
丘比特应助白芷当归采纳,获得10
3秒前
领导范儿应助猪猪hero采纳,获得10
3秒前
4秒前
znn发布了新的文献求助10
4秒前
4秒前
Iruri完成签到 ,获得积分20
4秒前
4秒前
4秒前
4秒前
黄茹发布了新的文献求助10
5秒前
Dannnn发布了新的文献求助10
5秒前
yina发布了新的文献求助10
6秒前
爆米花应助tao采纳,获得10
6秒前
6秒前
DijiaXu应助朴实白卉采纳,获得20
7秒前
英俊的铭应助随波逐流采纳,获得10
7秒前
Miayoyo发布了新的文献求助20
7秒前
zhhl2006发布了新的文献求助10
8秒前
迅速寻桃发布了新的文献求助10
9秒前
CNJX完成签到,获得积分10
9秒前
无花果应助黑黑黑采纳,获得10
9秒前
我是老大应助風声鶴唳采纳,获得10
9秒前
9秒前
英俊的铭应助给我一块钱采纳,获得10
10秒前
慕青应助曾经的背包采纳,获得10
11秒前
leo_zjm发布了新的文献求助10
11秒前
秀丽的正豪完成签到,获得积分10
11秒前
封闭货车完成签到 ,获得积分10
12秒前
12秒前
12秒前
13秒前
13秒前
杨桃完成签到,获得积分10
13秒前
小学生发布了新的文献求助10
13秒前
Bio应助哈哈哈哈哈哈12306采纳,获得30
14秒前
NexusExplorer应助杨洋采纳,获得10
14秒前
14秒前
高分求助中
Picture Books with Same-sex Parented Families: Unintentional Censorship 700
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
Effective Learning and Mental Wellbeing 300
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3974712
求助须知:如何正确求助?哪些是违规求助? 3519159
关于积分的说明 11197254
捐赠科研通 3255257
什么是DOI,文献DOI怎么找? 1797724
邀请新用户注册赠送积分活动 877130
科研通“疑难数据库(出版商)”最低求助积分说明 806132