Neutrophils and neutrophil extracellular trap components: Emerging biomarkers and therapeutic targets for age-related eye diseases

黄斑变性 中性粒细胞胞外陷阱 糖尿病性视网膜病变 炎症 青光眼 医学 发病机制 小梁网 视网膜病变 免疫学 生物信息学 生物 糖尿病 眼科 内分泌学
作者
Irene Martínez‐Alberquilla,Xavier Gasull,Patricia Pérez-Luna,Rubén Seco-Mera,Javier Ruiz‐Alcocer,Almudena Crooke
出处
期刊:Ageing Research Reviews [Elsevier BV]
卷期号:74: 101553-101553 被引量:29
标识
DOI:10.1016/j.arr.2021.101553
摘要

Age-related eye diseases, including dry eye, glaucoma, age-related macular degeneration, and diabetic retinopathy, represent a major global health issue based on their increasing prevalence and disabling action. Unraveling the molecular mechanisms underlying these diseases will provide novel opportunities to reduce the burden of age-related eye diseases and improve eye health, contributing to sustainable development goals achievement. The impairment of neutrophil extracellular traps formation/degradation processes seems to be one of these mechanisms. These traps formed by a meshwork of DNA and neutrophil cytosolic granule proteins may exacerbate the inflammatory response promoting chronic inflammation, a pivotal cause of age-related diseases. In this review, we describe current findings that suggest the role of neutrophils and their traps in the pathogenesis of the above-mentioned age-related eye diseases. Furthermore, we discuss why these cells and their constituents could be biomarkers and therapeutic targets for dry eye, glaucoma, age-related macular degeneration, and diabetic retinopathy. We also examine the therapeutic potential of some neutrophil function modulators and provide several recommendations for future research in age-related eye diseases.
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