Progress in Synthesis of 2-Substituted Benzothiazole Compounds

The application and research of 2-substituted benzothiazoles in biomedicine, materials science and other fields have made their synthetic methods widely concerned.Based on the research of traditional synthetic methods, the development of new methods such as elemental sulfur-mediated redox reaction and dehydroaromatization of saturated compounds could provide more possibilities for the synthesis of benzothiazole derivatives.In addition, the application of new metal-organic framework catalysts, combined ionic liquids/gels, ultrasound and microwave assist in recent years have greatly enriched the synthesis of benzothiazole derivatives.The synthetic method of 2-substituted benzothiazoles in recent years is analyzed.