再狭窄
自噬
体内
内膜增生
静脉
间充质干细胞
医学
化学
内科学
外科
病理
生物
支架
平滑肌
生物化学
细胞凋亡
生物技术
作者
Tianshu Chu,Chun Dai,Xiang Li,Lei Gao,Hongyan Yin,Jianjun Ge
出处
期刊:Biomaterials advances
[Elsevier BV]
日期:2022-05-02
卷期号:137: 212836-212836
被引量:3
标识
DOI:10.1016/j.bioadv.2022.212836
摘要
Following vein grafting, the vein must adapt to arterial hemodynamics, which can lead to intimal hyperplasia (IH) and restenosis. Moreover, endothelial-to-mesenchymal transition (EndMT) components are highly associated with IH. Therefore, in this study, we aimed to design an extravascular film loaded with rapamycin (extravascular rapamycin film [ERF]) to limit vein graft stenosis. The film exhibited stable physicochemical properties as well as in vivo and in vitro biocompatibility. In vivo, the film inhibited the EndMT by activating the autophagy pathway. Moreover, rapamycin enhanced this biological effect. Collectively, these findings highlighted the applicability of ERF as a new therapeutic target for preventing vein graft restenosis.
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