医学
慢性咳嗽
吸入
咳嗽反射
耐火材料(行星科学)
干扰素
痰
免疫学
γ干扰素
内科学
胃肠病学
药理学
作者
Jiayang Sun,Chen Zhan,Zheng Deng,Wei Luo,Qiaoli Chen,Mei Jiang,Nanshan Zhong,Kefang Lai
出处
期刊:Thorax
[BMJ]
日期:2022-01-07
卷期号:: thoraxjnl-218403
标识
DOI:10.1136/thoraxjnl-2021-218403
摘要
Chronic refractory cough (CRC) is characterised by cough hypersensitivity. Interferon-γ (IFN-γ) has been reported to induce calcium influx, action potentials of vagal neurons in vitro and cough response in guinea pigs. While the effect of IFN-γ in CRC patients remains unknown. Here, via flow-cytometry and inhalation cough challenge, we found CRC patients had significantly increased levels of sputum IFN-γ + CD4 + T cells, IFN-γ + CD8 + T cells as well as supernatant of IFN-γ. The average number of coughs in CRC patients increased as the concentration of inhaled IFN-γ went up in IFN-γ cough challenge. Two or more coughs and five or more coughs elicited by inhaled IFN-γ in CRC patients occurred in 7 of 10 and 2 of 10, respectively. Preinhaled IFN-γ (100 µg/mL) increased the capsaicin cough sensitivity in CRC patients but not healthy volunteers. Targeting IFN-γ may be a potential effective anti-tussive strategy in CRC patients.
科研通智能强力驱动
Strongly Powered by AbleSci AI