Multienzymatic Antioxidant Activity of Manganese-Based Nanoparticles for Protection against Oxidative Cell Damage

Oxidative stress is related to many diseases, but available clinical treatment methods are currently limited. Exploitation of enzyme-mimicking nanomaterials (nanozymes) is a promising way for scavenging reactive oxygen species (ROS) and treatment of ROS-related diseases. Herein, the catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx) mimicking activities are expressed by MnO2 nanoparticles (MnO2-BSA NPs) coated with BSA. Effective •OH removal activity is also expressed by MnO2-BSA NPs at neutral pH. Apoptosis inhibition and ROS scavenging capabilities of MnO2-BSA NPs are evident on the H2O2-exposed BEAS-2B cells line. Western blot analysis indicates that MnO2-BSA NPs inhibit H2O2-induced apoptosis by mediating the expression of apoptosis-related proteins.