介孔二氧化硅
化学
阿霉素
内吞作用
纳米颗粒
毒品携带者
癌细胞
丙烯酸
生物物理学
药理学
共聚物
药物输送
癌症
材料科学
生物化学
纳米技术
细胞
介孔材料
化疗
医学
有机化学
聚合物
外科
生物
内科学
催化作用
作者
Hae-Soo Lee,Miseop Choi,Ha Eun Kim,Minki Jin,Woojin Jeon,Minwoo Jung,Hyelim Yoo,Jong-Hee Won,Young‐Guk Na,Jae‐Young Lee,Hasoo Seong,Hong-Ki Lee,Cheong‐Weon Cho
标识
DOI:10.1016/j.jconrel.2022.06.064
摘要
Although mesoporous silica nanoparticles (MSNs) are widely used as anticancer drug carriers, unmodified MSNs induce off-target effects and at high doses, there are adverse effects of hemolysis because of the interaction with the silanol group on the surface and cells. In this study, we developed doxorubicin (DOX)-loaded MSNs coated with mannose grafted poly (acrylic acid) copolymer ([email protected]–man-g-PAA) to enhance the hemocompatibility and target efficacy to cancer cells. This uniform nanosized [email protected]–man-g-PAA showed sustained and pH-dependent drug release with improved hemocompatibility over the bare MSNs. The uptake of the [email protected]–man-g-PAA in breast cancer cells was significantly improved by mannose receptor-mediated endocytosis, which showed significant increasing intracellular ROS and changes in mitochondrial membrane potential. This formulation exhibited superior tumor-suppressing activity in the MDA-MB-231 cells inoculated mice. Overall, the present study suggested the possibility of the copolymer-coated MSNs as drug carriers for cancer therapy.
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