Food-Grade Quercetin-Loaded Nanoemulsion Ameliorates Effects Associated with Parkinson’s Disease and Cancer: Studies Employing a Transgenic C. elegans Model and Human Cancer Cell Lines

槲皮素 秀丽隐杆线虫 转基因 转基因小鼠 癌症 疾病 癌细胞 人类疾病 癌症研究 生物 药理学 医学 抗氧化剂 生物化学 基因 内科学 遗传学
作者
Sabya Sachi Das,Arunabh Sarkar,Siva Chander Chabattula,Priya Ranjan Prasad Verma,Aamir Nazir,Piyush Kumar Gupta,Janne Ruokolainen,Kavindra Kumar Kesari,Sandeep Kumar Singh
出处
期刊:Antioxidants [Multidisciplinary Digital Publishing Institute]
卷期号:11 (7): 1378-1378 被引量:22
标识
DOI:10.3390/antiox11071378
摘要

A nanosized food-grade quercetin-loaded nanoemulsion (QNE) system comprising capmul MCM NF (oil) and cremophor RH 40 (surfactant) was developed using a high-speed homogenization technique. The developed QNE was studied for its significant neuroprotective (anti-Parkinsonism) and cytotoxicity (anticancer) effects against Caenorhabditis elegans (C. elegans) strains and human cancer cells, respectively. HR-TEM studies revealed that the QNE was spherical with a mean globule size of ~50 nm. Selected area electron diffraction (SAED) studies results demonstrated that QNE was amorphous. In vivo results show that QNE potentially reduced the α-Syn aggregation, increased mitochondrial and fat content, and improved the lifespan in transgenic C. elegans strain NL5901. QNE significantly downregulated the reactive oxygen species (ROS) levels in wild-type C. elegans strain N2. In vitro results of the MTT assay show that QNE significantly exhibited chemotherapeutic effects in all treated human cancer cells in an order of cytotoxicity: HeLa cells > A549 cells > MIA PaCa-2 cells, based on the IC50 values at 24 h. Conclusively, the QNE showed improved solubility, targetability, and neuroprotective effects against the PD-induced C. elegans model, and also cytotoxicity against human cancer cells and could be potentially used as an anti-Parkinson’s or anticancer agent.
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