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Integrated analysis reveals prognostic value and progression-related role of AMIGO2 in prostate cancer

列线图 前列腺癌 肿瘤科 比例危险模型 单变量 医学 生存分析 内科学 癌症 阶段(地层学) 单变量分析 多元分析 多元统计 生物 统计 古生物学 数学
作者
Zhaodong Han,Yuanfa Feng,Yulin Deng,Zhenfeng Tang,Shanghua Cai,Yangjia Zhuo,Yingke Liang,Jian‐Heng Ye,Zhouda Cai,Shuai Yang,Yuxiang Liang,Chi Tin Hon,Jia-Hong Chen,Weide Zhong
出处
期刊:Translational Andrology and Urology [AME Publishing Company]
卷期号:11 (7): 914-928 被引量:7
标识
DOI:10.21037/tau-21-1148
摘要

Even though emerging studies supplied evidence that Adhesion Molecule with Ig Like Domain family 2 (AMIGO2) plays a critical role in numerous cancers, comprehensive analysis of the prognostic value and significant role of AMIGO2 in prostate cancer (PCa) have not been described.Differentially expressed analysis, survival analysis and univariate cox regression analysis were first performed to explore the diagnostic and prognostic role of AMIGO2 in various cancers, especially in PCa. Tissue microarray were used to examined the association between AMGIO2 and clinical features. Multivariate cox regression analysis, concordance index, nomogram construction, the receiver operator characteristic curve and calibration curves were further used to discover the effects of AMIGO2 on recurrence-free survival (RFS) and clinicopathological characteristics, including age, Gleason score (GS) and tumor stage. Genetic and Epigenetic Alterations analysis were further conducted to explore the potential effect of AMIGO2 in PCa and examined by biological function analysis and in vitro experiments.AMIGO2 was associated with poor RFS (P<0.05) and differentially expressed (P<0.05) in multiple cancer type, especially in PCa. Besides, decreasing the expression of AMIGO2 inhibited PCa cell proliferation and colony formation in vitro. In addition, AMIGO2 was a reliable prognostic marker providing additional information (C-index: 0.7) that supplement the currently used prognosis evaluation system, e.g., T stage (C-index: 0.62) and GS (C-index: 0.65). A novel nomogram was established based on AMIGO2, tumor stage and GS with accuracies (areas under curve) of 0.70, 0.78 and 0.82 for predicting 3-, 5- and 7-year RFS, respectively. Bioinformatic analysis and in vitro examination also suggested that AMIGO2 might involve in the progression of PCa tumors inducing epithelial mesenchymal transition (EMT).We identified AMIGO2 as a pan-cancer gene that could not only be a prognostic biomarker in various cancers, especially in PCa, but may functionally promoting PCa progression via EMT and mediating docetaxel resistance, suggesting AMIGO2 as a potential target for future treatment of PCa.
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