A Review on Convolutional Neural Networks for Brain Tumor Segmentation: Methods, Datasets, Libraries, and Future Directions

Accurate and reliable segmentation of brain tumors from MRI images helps in planning an enhanced treatment and increases the life expectancy of patients. However, the manual segmentation of brain tumors is subjective and more prone to errors. Nonetheless, the recent advances in convolutional neural network (CNN)-based methods have exhibited outstanding potential in robust segmentation of brain tumors. This article comprehensively investigates recent advances in CNN-based methods for automatic segmentation of brain tumors from MRI images. It examines popular deep learning (DL) libraries/tools for an expeditious and effortless implementation of CNN models. Furthermore, a critical assessment of current DL architectures is delineated along with the scope of improvement. In this work, more than 50 scientific papers from 2014-2020 are selected using Google Scholar and PubMed. Also, the leading journals related to our work along with proceedings from major conferences such as MICCAI, MIUA and ECCV are retrieved. This research investigated various annual challenges too related to this work including Multimodal Brain Tumor Segmentation Challenge (MICCAI BRATS) and Ischemic Stroke Lesion Segmentation Challenge (ISLES). After a systematic literature search pertinent to the theme, we found that principally there exist three variations of CNN architecture for brain tumor segmentation: single-path and multi-path, fully convolutional, and cascaded CNNs. The respective performances of most automated methods based on CNN are appraised on the BraTS dataset, provided as a part of the MICCAI Multimodal Brain Tumor Segmentation challenge held annually since 2012. Notwithstanding the remarkable potential of CNN-based methods, reliable and robust segmentation of brain tumors continues to be an intractable challenge. This is due to the intricate anatomy of the brain, variability in its appearance, and imperfection in image acquisition. Moreover, owing to the small size of MRI datasets, CNN-based methods cannot operate with their full capacity, as demonstrated with large scale datasets, such as ImageNet.