Mechanisms of Transgelin-2 in Tumorigenesis.

Actin-binding protein (transgelin, TAGLN) is a kind of protein that regulates actin polymerization, aggregating (or bundling), or cross-linking. As a member of the actin-binding protein complex, transgelin-2 is involved in the regulation of cytoskeleton. Transgelin-2 is widely expressed in various tissues and organs of the body, but its abnormal expression is often seen in all kinds of tumors, which is related to the occurrence and development, and especially the invasion, metastasis, and drug resistance in many kinds of malignant tumors. However, the signal pathway involved in the regulation of transgelin-2 and its mechanism have remained to be elucidated. In recent years, with a more in-depth study of transgelin-2, its relationship with tumorigenesis has become increasingly clear. Therefore, we review recent research progress in transgelin-2, which is helpful to provide ideas for further research and bring forth a new scheme for the diagnosis, treatment, and prognosis of tumors.