Microrobotic carrier with enzymatically encoded drug release in the presence of pancreatic cancer cells via programmed self-destruction

聚己内酯 生物相容性 纳米技术 纳米机器人学 材料科学 药品 胰腺癌 纳米医学 靶向给药 磁性纳米粒子 化学
作者
Marta Pacheco,Carmen C. Mayorga-Martinez,Jitka Viktorova,Tomáš Ruml,Alberto Escarpa,Martin Pumera
出处
期刊:Applied Materials Today [Elsevier]
卷期号:27: 101494-101494
标识
DOI:10.1016/j.apmt.2022.101494
摘要

• Magnetic microrobots are based on microspheres made of polycaprolactone (PCL), Fe 3 O 4 and contain the anticancer drug. • Lipase triggers the drug release from the micromachines through biodegradation of PCL. • These microrobots are tool for programmable drug release. The field of micro/nanorobots is at the forefront of nanotechnology research. Particularly, magnetically propelled micro/nanorobots demonstrate great potential for biomedical applications due to their biocompatibility in biological environments. Herein is a concept of magnetically powered micromachines with a biodegradable polymer and layer containing an incorporated anticancer drug. The microrobot is chemically programmed in such a way that the polymer layer is degraded by the enzymatic activity of lipase, which is overexpressed in pancreatic cancer cells. This causes degradation of the microrobot's polymer layer and, thus, destruction of this robot, releasing the anticancer drug, which in turn kills the pancreatic cancer cell. Magnetic microrobots are based on microspheres made of polycaprolactone (PCL), iron oxide nanoparticles (Fe 3 O 4 ), and coated polyethyleneimine (PEI) micelles containing the anticancer drug. Lipase, naturally overexpressed specifically in pancreatic cancer cells, triggers the drug release from the micromachines through biodegradation of PCL. The developed PCL-Fe 3 O 4 /PEI magnetic microrobots are fully biocompatible and represent a promising tool for programmable drug release that may be useful in many biomedical applications.
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