The impact of tobacco smoking on survival of patients with oral squamous cell carcinoma: a population-based retrospective study

医学 比例危险模型 内科学 危险系数 基底细胞 戒烟 回顾性队列研究 肿瘤科 人口 饮酒量 生存分析 流行病学 外科 病理 置信区间 环境卫生 化学 生物化学
作者
Amanda Oester Andersen,Jakob Schmidt Jensen,Kathrine Kronberg Jakobsen,Helene Stampe,Kristoffer Juul Nielsen,Irene Wessel,Anders Christensen,Elo Andersen,Jeppe Friborg,Christian Grønhøj,Christian von Buchwald
出处
期刊:Acta Oncologica [Taylor & Francis]
卷期号:61 (4): 449-458 被引量:6
标识
DOI:10.1080/0284186x.2022.2033830
摘要

This article aims to evaluate the impact of smoking status, accumulated tobacco exposure (ATE), and smoking cessation on overall- and disease-free survival (OS and DFS) of patients with oral squamous cell carcinoma (OSCC).Patients with primary OSCC treated with curative intent between 2000 and 2019 in Copenhagen were included (n = 1808). Kaplan-Meier curves and multivariable Cox regression analyses were performed to compare the survival of patients with different smoking history. Interactions between ATE and (A) tumor subsite and (B) excessive alcohol consumption (EAC) on the survival were evaluated using multivariable Cox regression analyses with interaction terms.We included 1717 patients with known smoking status (62.8% males, median age: 64 years (IQR: 57-71 years)), who had a 5-year OS of 53.7% (95%CI: 49.8%-57.9%). Based on fully adjusted multivariable Cox regression analyses, significantly elevated hazard ratios (HRs) for OS and DFS were identified for current, but not former smokers, compared to never-smokers. An approximately linear relationship between continuous ATE and survival estimates was identified. ATE analyzed as a categorical variable showed significantly elevated HRs for OS of patients with all categories (060 PYs), however only for DFS of patients with >60 PYs, compared to 0 PYs. Furthermore, an unfavorable long-term prognosis was evident after >3.5 (OS) and >2.5 (DFS) years from diagnosis for patients who continued smoking compared to patients with smoking cessation at diagnosis. The survival estimates of patients with different tumor subsite and alcohol consumption differed with increasing ATE.Tobacco smoking (assessed as smoking status and ATE) was associated with inferior survival (OS and DFS) among patients with OSCC. Unfavorable long-term prognosis was significant for patients who continued smoking compared to patients with smoking cessation at diagnosis. The impact of ATE on survival of patients with OSCC may depend on the tumor subsite and/or alcohol consumption.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
CJW完成签到 ,获得积分10
1秒前
韧迹完成签到 ,获得积分0
1秒前
mmd完成签到 ,获得积分10
1秒前
七一安完成签到 ,获得积分10
2秒前
浪麻麻完成签到 ,获得积分10
6秒前
包容的剑完成签到 ,获得积分10
10秒前
等待的大炮完成签到,获得积分10
10秒前
注水萝卜完成签到 ,获得积分10
12秒前
Chem34完成签到,获得积分10
20秒前
22秒前
量子星尘发布了新的文献求助10
22秒前
hhh2018687完成签到,获得积分10
22秒前
22秒前
23秒前
23秒前
23秒前
23秒前
24秒前
24秒前
24秒前
24秒前
24秒前
24秒前
24秒前
嘒彼小星完成签到 ,获得积分10
24秒前
24秒前
25秒前
25秒前
25秒前
25秒前
26秒前
ri_290完成签到,获得积分10
26秒前
27秒前
nsc发布了新的文献求助30
29秒前
nsc发布了新的文献求助10
29秒前
nsc发布了新的文献求助10
29秒前
nsc发布了新的文献求助10
29秒前
nsc发布了新的文献求助10
29秒前
nsc发布了新的文献求助10
29秒前
nsc发布了新的文献求助10
29秒前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Handbook of Industrial Diamonds.Vol2 1100
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038039
求助须知:如何正确求助?哪些是违规求助? 3575756
关于积分的说明 11373782
捐赠科研通 3305574
什么是DOI,文献DOI怎么找? 1819239
邀请新用户注册赠送积分活动 892655
科研通“疑难数据库(出版商)”最低求助积分说明 815022