与抗原处理相关的转运体
MHC I级
川东北74
细胞生物学
内质网
抗原处理
主要组织相容性复合体
抗原呈递
MHC限制
MHC II级
伴侣(临床)
化学
生物
抗原
T细胞
免疫系统
免疫学
医学
病理
作者
Yan Jiang,Noriko Arase,Masako Kohyama,Kouyuki Hirayasu,Tadahiro Suenaga,Hui Jin,Maki Matsumoto,Kyoko Shida,Lewis L. Lanier,Takashi Saito,Hisashi Arase
标识
DOI:10.1093/intimm/dxs155
摘要
Abstract Nascent MHC class II molecules are associated with the invariant chain and are transported to the endolysosomal pathway, where MHC class II molecules acquire peptide antigens. On the other hand, misfolded endoplasmic reticulum (ER) proteins are generally degraded in the cells and are neither expressed on the cell surface nor secreted. Here, we found that MHC class II molecules associate with some misfolded ER proteins via the peptide-binding groove in competition with invariant chain. The misfolded proteins associated with MHC class II molecules are transported intact to the cell surface without processing to peptides. Furthermore, these complexes efficiently stimulate antigen-specific B cells. These findings reveal that MHC class II molecules function as a chaperone for the cell surface expression of misfolded ER proteins. In addition, we suggest that MHC class II molecules present not only peptides but also intact host-cell-derived proteins on the cell surface. These findings provide new insights into the function of MHC class II molecules.
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