维甲酸
维甲酸受体γ
维甲酸受体
维甲酸诱导孤儿G蛋白偶联受体
维甲酸受体β
核受体
维甲酸受体α
受体
胞浆
细胞生物学
细胞生长
细胞核
生物化学
生物
化学
核心
转录因子
基因
酶
出处
期刊:Nutrition Reviews
[Oxford University Press]
日期:2008-02-01
卷期号:66 (1): 55-59
被引量:40
标识
DOI:10.1111/j.1753-4887.2007.00006.x
摘要
Retinoic acid can combine with the nuclear retinoic acid receptor (RAR), leading to cell growth inhibition, as in certain tumors. Retinoic acid can also bind to the orphan nuclear receptor peroxisome proliferator-activated receptor β/δ (PPARβ/δ), resulting in stimulation of cell growth and inhibition of apoptosis. To bind to RAR, retinoic acid is carried into the nucleus by the cytosolic cellular retinoic acid-binding protein-II; to bind to PPARβ/δ, it is transported into the nucleus by the cytosolic fatty acid-binding protein 5.
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