Disease-related Risk of Vertebral Fracture During Glucocorticoid Treatment of Collagen Vascular Diseases

医学 内科学 骨质疏松症 类风湿性关节炎 结缔组织病 糖皮质激素 泼尼松龙 皮肌炎 胃肠病学 多发性肌炎 混合性结缔组织病 疾病 自身免疫性疾病
作者
Ichiro Tatsuno,Sawako Suzuki,Tomohiko Yoshida,Hidekazu Nagano,Naoko Hashimoto,Takafumi Mayama,Tomoaki Tanaka,Takao Sugiyama
出处
期刊:The Journal of Rheumatology [The Journal of Rheumatology Publishing Company Limited]
卷期号:38 (10): 2270-2272 被引量:3
标识
DOI:10.3899/jrheum.110412
摘要

To the Editor: Collagen vascular diseases, including systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), Sjögren’s syndrome (SS), systemic sclerosis (SSc)/mixed connective tissue disease (MCTD), polymyositis/dermatomyositis (PM/DM), and microscopic polyangiitis, are chronic and sometimes involve multiple organs, and are thus occasionally life-threatening. Immunosuppressive treatment with longterm high-dose glucocorticoids is necessary, but the treatment causes a high incidence of osteoporosis1,2,3. Recently, we demonstrated that patients treated with longterm high-dose glucocorticoids have a high risk of symptomatic vertebral fractures in collagen vascular diseases, based on the analysis of the Chiba-Shimoshizu Rheumatic Cohort4,5. The chronic and systemic inflammation in patients with RA and SLE has been recognized as causing secondary osteoporosis independently of glucocorticoids6, and many studies demonstrated that patients with RA have lower bone mineral density (BMD) and an increased risk of fracture7,8,9. However, it was not known whether there is a disease-specific or disease-related risk of osteoporotic fracture under glucocorticoid treatment among the collagen vascular diseases. We investigated the disease-specific or disease-related risk for osteoporotic symptomatic vertebral fracture by focusing on women treated with high-dose glucocorticoids for the long term for collagen vascular diseases, subanalyzing a cohort at Shimoshizu National Hospital in Japan. The study subjects were newly treated with an initial dose of > 20 mg/day prednisolone (PSL) equivalent for at least 6 months without prior prophylactic treatment with bisphosphonate, hormone replacement therapy, or selective estrogen receptor modulator to prevent bone loss. We defined glucocorticoid dose increase as the reintroduction of ≥ 20 mg/day of glucocorticoid (PSL equivalent) due to increased disease activity in patients whose doses were once tapered to < 20 mg/day. Symptomatic vertebral fracture was defined as vertebral deformity that was confirmed … Address correspondence to Dr. I. Tatsuno, Department of Clinical Cell Biology, Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chuo-ku, Chiba, 260-8670, Japan. E-mail: ichiro-tatsuno{at}faculty.chiba-u.jp

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
宇宇宇c完成签到,获得积分10
1秒前
zxt完成签到,获得积分10
2秒前
大橙子发布了新的文献求助10
5秒前
聪明静柏完成签到 ,获得积分10
7秒前
kimiwanano完成签到,获得积分10
9秒前
lu完成签到,获得积分10
10秒前
Profeto应助齐嫒琳采纳,获得10
11秒前
12秒前
情怀应助科研通管家采纳,获得10
13秒前
从来都不会放弃zr完成签到,获得积分10
17秒前
1459完成签到,获得积分10
19秒前
行者+完成签到,获得积分10
19秒前
GongSyi完成签到 ,获得积分10
20秒前
Boris完成签到 ,获得积分10
22秒前
哭泣笑柳完成签到,获得积分10
22秒前
万能图书馆应助大橙子采纳,获得10
25秒前
大眼睛土豆完成签到,获得积分10
29秒前
一条虫gg完成签到,获得积分10
32秒前
33秒前
34秒前
37秒前
大橙子发布了新的文献求助10
37秒前
dzy发布了新的文献求助10
41秒前
故意的冰淇淋完成签到 ,获得积分10
42秒前
司藤完成签到 ,获得积分10
43秒前
niumi190完成签到,获得积分0
43秒前
温馨完成签到 ,获得积分10
45秒前
东方琉璃完成签到,获得积分10
46秒前
47秒前
刘闹闹完成签到 ,获得积分10
48秒前
量子星尘发布了新的文献求助10
49秒前
雅3165完成签到 ,获得积分10
49秒前
53秒前
54秒前
狂野元枫完成签到 ,获得积分10
56秒前
ruochenzu发布了新的文献求助10
59秒前
大葱鸭发布了新的文献求助10
59秒前
ABC完成签到,获得积分20
1分钟前
原本发布了新的文献求助10
1分钟前
dzy完成签到,获得积分20
1分钟前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Handbook of Industrial Diamonds.Vol2 1100
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038157
求助须知:如何正确求助?哪些是违规求助? 3575869
关于积分的说明 11373842
捐赠科研通 3305650
什么是DOI,文献DOI怎么找? 1819255
邀请新用户注册赠送积分活动 892655
科研通“疑难数据库(出版商)”最低求助积分说明 815022