内分泌学
内科学
催产素
囊泡单胺转运体2
儿茶酚胺
去甲肾上腺素转运体
肾上腺髓质
单胺类神经递质
去甲肾上腺素
囊泡单胺转运体
神经肽Y受体
肾上腺素
化学
甘丙肽
生物
神经肽
多巴胺
医学
血清素
受体
作者
Predrag Jovanović,Nataša Spasojević,Bojana Stefanović,Nikola Božović,Nebojša Jasnić,Jelena Djordjević,Sladjana Dronjak
出处
期刊:Peptides
[Elsevier]
日期:2013-11-12
卷期号:51: 110-114
被引量:5
标识
DOI:10.1016/j.peptides.2013.11.001
摘要
The neuropeptide oxytocin has been shown to influence on neuroendocrine function. The aim of the present study was to investigate the effect of peripheral oxytocin treatment on the synthesis, uptake and content of adreno-medullary catecholamine. For this purpose oxytocin (3.6 μg/100 g body weight, s.c) was administrated to male rats once a day over 14 days. In order to assess the effect of peripheral oxytocin treatment on adreno-medullary catecholamine we measured epinephrine and norepinephrine content and gene expression of tyrosine hydroxylase (TH), norepinephrine transporter (NET) and vesicular monoamine transporter 2 (VMAT2) in the adrenal medulla. Our results show a significant increase of epinephrine (1.7-fold, p < 0.05) and norepinephrine (1.5-fold, p < 0.05) content in oxytocin treated animals compared to saline treated ones. Oxytocin treatment had no effect either on mRNA or protein level of TH and NET. Under oxytocin treatment the increase in VMAT2 mRNA level was not statistically significant, but it caused a significant increase in protein level of VMAT2 (3.7-fold, p < 0.001). These findings indicate that oxytocin treatment increases catecholamine content in the rat adrenal medulla modulating VMAT2 expression.
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