电穿孔
计算机科学
嵌入式系统
计算机硬件
电气工程
工程类
化学
生物化学
基因
作者
Congo Tak‐Shing Ching,Tai–Ping Sun,Wei‐Ti Huang,Su-Hua Huang,Chin-Sung Hsiao,Kang-Ming Chang
标识
DOI:10.1016/j.snb.2012.02.065
摘要
Abstract Electroporation for transdermal drug delivery or for non-invasive monitoring of patients could allow a new generation of medical devices to be developed for low-cost healthcare. The existing electroporation systems today are bulky, expensive or not fully programmable. Therefore, a compact, low-cost and programmable device was developed and evaluated. A circuit is described herein which provides a variety of adjustable high-voltage (2–300 V) electric waveforms (pulsed and pulsed-biphasic) for electroporation. Evaluation showed that this device provides for precise regulation of the magnitude and waveform of a high-voltage over a wide range of impedance, important for in vivo /human use. Also, the device was evaluated in vitro to be capable of enhancing transdermal extraction of metabolites, like uric acid, for non-invasive monitoring and transdermal delivery of medications, like insulin, for non-invasive drug delivery.
科研通智能强力驱动
Strongly Powered by AbleSci AI