副结核
免疫系统
生物
亚临床感染
免疫学
免疫
T细胞
体液免疫
细胞免疫
疾病
分枝杆菌
微生物学
病毒学
细菌
医学
遗传学
病理
标识
DOI:10.1016/s0378-1135(00)00331-x
摘要
The host immune response to infection with Mycobacterium paratuberculosis is paradoxical, with strong cell-mediated immune responses during the early, subclinical stages of infection and strong humoral responses during the late clinical stages of the disease. Cell-mediated immune responses modulated by various T cell subsets are essential to provide protective immunity and prevent progression of the disease. Secretion of cytokines by T cell populations serves to activate macrophages to kill ingested M. paratuberculosis as well as activate other T cell subsets to contain the infection. This paper reviews the current knowledge of T cell immune responses in M. paratuberculosis infection based upon clinical studies and research using mouse models.
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