A method for removal of N-BOC protecting groups from substrates on TFA-sensitive resins

N-Tert-butyloxycarbonyl groups can be removed from substrates supported on Rink's amide resin by treatment with trimethylsilyl triflate/2,6-lutidine. This methodology was illustrated here with syntheses of several peptides, but it is likely to be used more extensively in solid phase syntheses of small molecule libraries.