延髓头端腹外侧区
伪狂犬病
脊髓
生物
延髓
绿色荧光蛋白
髓质
神经科学
细胞生物学
病毒
解剖
中枢神经系统
病毒学
基因
遗传学
作者
Cheng-Jin Yue,Feng Li,Qi Huang
出处
期刊:PubMed
日期:2014-01-01
卷期号:7 (11): 7962-6
被引量:4
摘要
Pseudorabies virus (PRV)-614 was injected into the tracheal wall of male MC4R-GFP transgenic mice, resulting in retrograde infections in spinal cord and autonomic premotor areas of the brain including the rostroventrolateral medulla (RVLM). This polysynaptic pathway to the airway may form the substrate underlying the impact of IML and RVLM on airway function. The neurochemical phenotype of MC4R-GFP-positive neurons was identified using fluorescence immunocytochemical labeling. PRV-614/MC4R-GFP dual labeled neurons were detected in spinal IML and the rostral ventrolateral medulla (RVLM). These data demonstrate the RVLM-IML pathway of synaptically connected neurons extending to the airway through melanocortinergic-sympathetic signaling.
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