脱羧
光催化
立体选择性
化学
催化作用
产量(工程)
肉桂酸
光催化
芳基
有机化学
组合化学
材料科学
冶金
烷基
作者
Xiao‐Jing Wei,Wout Boon,Volker Hessel,Timothy Noël
标识
DOI:10.1021/acscatal.7b03019
摘要
The development of synthetic methodologies which provide access to both stereoisomers of α,β-disubstituted olefins is a challenging undertaking. Herein, we describe the development of an operationally simple and stereoselective synthesis of difluoromethylated styrenes via a visible-light photocatalytic decarboxylation strategy using fac-Ir(ppy)3 as the photocatalyst. Meta- and para-substituted cinnamic acids provide the expected E-isomer. In contrast, ortho-substituted cinnamic acids yield selectively the less stable Z-product, whereas the E-isomer can be obtained via continuous-flow processing through accurate control of the reaction time. Furthermore, our protocol is amenable to the decarboxylative difluoromethylation of aryl propiolic acids.
科研通智能强力驱动
Strongly Powered by AbleSci AI