Quality of life and mood of patients and family caregivers during hospitalization for hematopoietic stem cell transplantation

医学 焦虑 医院焦虑抑郁量表 生活质量(医疗保健) 萧条(经济学) 移植 心情 内科学 造血干细胞移植 精神科 护理部 经济 宏观经济学
作者
Areej El‐Jawahri,Lara Traeger,Kailyn Kuzmuk,Janelle Eusebio,Harry VanDusen,Jennifer Shin,Tanya E. Keenan,Emily R. Gallagher,Joseph A. Greer,William F. Pirl,Vicki A. Jackson,Karen K. Ballen,Thomas R. Spitzer,Timothy A. Graubert,Steven L. McAfee,Bimalangshu R. Dey,Yi‐Bin Chen,Jennifer S. Temel
出处
期刊:Cancer [Wiley]
卷期号:121 (6): 951-959 被引量:176
标识
DOI:10.1002/cncr.29149
摘要

BACKGROUND We conducted a study to investigate the impact of hospitalization for hematopoietic stem cell transplantation (HCT) on the quality of life (QOL) and mood of patients and family caregivers (FC). METHODS We conducted a longitudinal study of patients who were hospitalized for HCT and their FC. We assessed QOL (using the Functional Assessment of Cancer Therapy‐Bone Marrow Transplantation) and mood (using the Hospital Anxiety and Depression Scale) at baseline (6 days before HCT), day +1, and day +8 of HCT. We administered the Medical Outcomes Study Health Survey Short Form‐36 to examine FC QOL (Physical Component Scale and Mental Component Scale). To identify predictors of changes in QOL, we used multivariable linear mixed models. RESULTS We enrolled 97% of eligible patients undergoing autologous (30 patients), myeloablative (30 patients), or reduced intensity (30 patients) allogeneic HCT. Patients' QOL markedly declined (mean Functional Assessment of Cancer Therapy‐Bone Marrow Transplantation score, 109.6 to 96.0; P <.0001) throughout hospitalization. The percentage of patients with depression (Hospital Anxiety and Depression Scale‐Depression score of >7) more than doubled from baseline to day +8 (15.6% to 37.8%; P <.0001), whereas the percentage of patients with anxiety remained stable (22.2%; P = .8). These results remained consistent when data were stratified by HCT type. Baseline depression (β, −2.24; F, 42.2 [ P <.0001]) and anxiety (β, −0.63; F, 4.4 [ P =.03]) were found to independently predict worse QOL throughout hospitalization. FC QOL declined during the patient's hospitalization (physical component scale: 83.1 to 79.6 [ P =.03] and mental component scale: 71.6 to 67.4 [ P =.04]). CONCLUSIONS Patients undergoing HCT reported a steep deterioration in QOL and substantially worsening depression during hospitalization. Baseline anxiety and depression predicted worse QOL during hospitalization, underscoring the importance of assessing pre‐HCT psychiatric morbidity. Cancer 2015;121:951–959. © 2014 American Cancer Society .
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
周芷卉发布了新的文献求助10
刚刚
MM完成签到,获得积分10
3秒前
LJJ完成签到 ,获得积分10
4秒前
杨紫琴完成签到,获得积分10
5秒前
7秒前
舒适映寒完成签到,获得积分10
9秒前
科研通AI2S应助123采纳,获得10
10秒前
erich完成签到 ,获得积分10
12秒前
之好完成签到,获得积分20
14秒前
煜琪发布了新的文献求助10
14秒前
夜阑听雨发布了新的文献求助50
17秒前
18秒前
songge完成签到,获得积分10
20秒前
Diego完成签到,获得积分10
21秒前
22秒前
DXM完成签到 ,获得积分10
22秒前
Ava应助萝卜不是菠萝采纳,获得10
24秒前
幽默的太阳完成签到 ,获得积分10
26秒前
JUGG完成签到,获得积分10
27秒前
之好发布了新的文献求助10
27秒前
29秒前
吉忆南发布了新的文献求助10
30秒前
30秒前
Jasper应助伶俐的甜瓜采纳,获得10
32秒前
33秒前
乾明少侠完成签到 ,获得积分10
34秒前
楼萌黑完成签到,获得积分10
34秒前
小玉发布了新的文献求助20
35秒前
dryao发布了新的文献求助10
38秒前
lllllll发布了新的文献求助10
40秒前
rosalieshi应助聆琳采纳,获得20
41秒前
46秒前
laihama完成签到,获得积分10
52秒前
123完成签到,获得积分10
53秒前
海纳百川发布了新的文献求助30
53秒前
小二郎应助科研通管家采纳,获得10
54秒前
简洁应助科研通管家采纳,获得20
54秒前
led应助科研通管家采纳,获得10
54秒前
54秒前
我是老大应助科研通管家采纳,获得10
54秒前
高分求助中
中国国际图书贸易总公司40周年纪念文集 大事记1949-1987 2000
TM 5-855-1(Fundamentals of protective design for conventional weapons) 1000
草地生态学 880
Threaded Harmony: A Sustainable Approach to Fashion 799
Basic Modern Theory of Linear Complex Analytic 𝑞-Difference Equations 550
中国有机(类)肥料 500
Queer Politics in Times of New Authoritarianisms: Popular Culture in South Asia 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3059778
求助须知:如何正确求助?哪些是违规求助? 2715655
关于积分的说明 7445758
捐赠科研通 2361283
什么是DOI,文献DOI怎么找? 1251388
科研通“疑难数据库(出版商)”最低求助积分说明 607751
版权声明 596467