医学
前列腺癌
PET-CT
正电子发射断层摄影术
核医学
生化复发
谷氨酸羧肽酶Ⅱ
内科学
放射科
前列腺
癌症
肿瘤科
标准摄取值
作者
Cigdem Soydal,Yuksel Urun,Evren Süer,Demet Nak,Elgin Ozkan,Nuriye Ozlem Kucuk
出处
期刊:Quarterly Journal of Nuclear Medicine and Molecular Imaging
[Edizioni Minerva Medica]
日期:2020-06-01
卷期号:64 (2): 226-230
被引量:2
标识
DOI:10.23736/s1824-4785.18.03056-x
摘要
BACKGROUND The aim of this study was to evaluate predictive factors of 68Gallium (68Ga) prostate-specific membrane antigen (PSMA) positron emission tomography (PET)/computed tomography (CT) positivity. METHODS Relationships between serum prostate specific antigen (PSA), lactate dehydrogenase (LDH) and alkaline phosphatase (ALP) levels, Gleason Score (GS) and positivity of 68Ga PSMA PET in patients who underwent 68Ga PSMA PET/CT for restaging for PCa were evaluated retrospectively. RESULTS One hundred and four (median age: 67; range: 51-88) patients were included in this study. Of these patients, PSMA PET was positive in 75 (72%) patients. Mean serum PSA levels for PET negative and positive groups were 0.76±1.00 and 180.85±324.93 ng/mL (P<0.001). The sensitivity and specificity of 68Ga PSMA PET/CT for detection of disease recurrence were calculated as 92% and 80%, respectively, for the 1.4 ng/mL PSA cut-off and 92% and 90%, respectively, for the 2 ng/mL PSA cut-off values. The positivity rates for patients with PSA levels <1.4 ng/mL and ≥1.4 ng/mL were 21% and 90%, respectively (P<0.001). CONCLUSIONS 68Ga PSMA PET/CT seems to be a highly sensitive in patients with early PSA recurrence. Patients with higher GS and early PSA recurrence could benefit from 68Ga PSMA PET/CT.
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