Self-powered portable melt electrospinning for in situ wound dressing

静电纺丝 纺纱 材料科学 聚己内酯 熔融纺丝 伤口敷料 复合材料 多孔性 纳米纤维 聚合物 纳米技术 化学 生物化学
作者
Yingtao Zhao,Jun Zhang,Yuan Gao,Xiaofei Liu,Jiangjun Liu,Xiao-Xiong Wang,Hongfei Xiang,Yun‐Ze Long
出处
期刊:Journal of Nanobiotechnology [Springer Nature]
卷期号:18 (1) 被引量:38
标识
DOI:10.1186/s12951-020-00671-w
摘要

Abstract Background Electrospun (e-spun) nanofibers for wound dressing have attracted wide attention due to its large specific surface area, large porosity and breathability. Compared with solution electrospinning (e-spinning), melt e-spinning is more bio-friendly without toxic solvent participation, which provides the possibility of in situ e-spinning on wounds directly. However, previously reported melt e-spinning devices were usually bulky and cumbersome due to their necessary heating unit, and different components were separated to avoid electrostatic interference. Results In this article, we report on a self-powered hand-held melt e-spinning gun which can work without any external power supply (outdoors). The problem of electrostatic interference for this integrated device was solved by using a special high heat transfer insulation unit. The apparatus is easy and safe to operate by a single hand due to its small volume (24 × 6 × 13 cm 3 ) and light weight (about 450 g). Some biodegradable polymers, for example, polycaprolactone (PCL) fibers were successful e-spun onto wounds directly by using this dressing gun. Conclusions PCL fibrous membrane has good biocompatibility and can be in situ electrospun to wound surface as a wound dressing by the portable melt e-spinning gun. Besides wound dressing, this hand-held melt e-spinning gun may be used in 3D printing and experimental teaching demonstration aids.

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