FGF21型
高强度间歇训练
内科学
内分泌学
医学
持续培训
间歇训练
肥胖
单调的工作
脂肪组织
塞德
超重
成纤维细胞生长因子
物理疗法
受体
作者
Yingzhe Xiong,Yan Chen,Yao Liu,Bing Zhang
出处
期刊:Biokhimiya
[Springer Nature]
日期:2020-08-01
卷期号:85 (8): 938-946
被引量:20
标识
DOI:10.1134/s000629792008009x
摘要
Fibroblast growth factor 21 (FGF21) and β-Klotho (KLB) play an important role in preventing and treating overweight and obesity. However, it is unclear what conditions promote FGF21 and KLB expression in different tissues. Therefore, we studied expression of FGF21 and KLB with respect to two exercise regimes: moderate-intensity continuous training (MICT) and high-intensity interval training (HIIT) (two popular strategies in weight loss). Mice were randomly divided into three groups (n = 8 per group): MICT, HIIT, and sedentary lifestyle (SED). All mice were fed a high-fat diet (HFD) for 12 weeks to induce obesity. The exercise was performed on a motorized treadmill for another eight weeks and the diet continued in each group. We found that both MICT and HIIT had positive effects on the loss of HFD-induced body weight increase and serum FGF21 levels. HIIT promoted decrease of the body weight and serum triglyceride (TG) levels, while MICT was more effective at enhancing FGF21 and KLB expression in the liver, brown adipose tissue (BAT), and muscle at the mRNA and protein levels.
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