缺血
神经保护
炎症
TLR4型
医学
神经科学
Toll样受体
受体
药理学
免疫学
内科学
生物
先天免疫系统
作者
Liangzhu Wang,Yingzhu Chen,Beilei Chen,Yang Liu,Hailong Yu
出处
期刊:Int J Cerebrovasc Dis
日期:2018-01-28
卷期号:26 (1): 63-67
标识
DOI:10.3760/cma.j.issn.1673-4165.2018.01.012
摘要
In recent years, studies have shown that inflammation is an important factor in secondary ischemic injury. The exploration of the related mechanisms of the occurrence of inflammation has become a hot spot in the field of cerebral ischemia. Toll-like receptor 4 (TLR4) signaling pathway is one of the classical inflammatory pathways. Studies have shown that TLR4 is involved in the early inflammatory response after cerebral ischemic injury and the late nerve repair. This article reviews the research progress of this signaling pathway in cerebral ischemia injury, so as to seek a therapeutic target against inflammatory injury caused by cerebral ischemia through the analysis of its potential research direction.
Key words:
Brain Ischemia; Toll-Like Receptor 4; Inflammation; Neuroprotective Agents; Ischemic Preconditioning
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