铱
癌症研究
细胞
肺癌
化学
癌症
细胞生物学
程序性细胞死亡
细胞凋亡
生物
医学
肿瘤科
生物化学
遗传学
催化作用
作者
Lili Wang,Ruilin Guan,Lina Xie,Xinxing Liao,Kai Xiong,Thomas W. Rees,Yu Chen,Gilles Gasser,Hui Chao
标识
DOI:10.1002/anie.202013987
摘要
Immunogenic cell death (ICD) is a vital component of therapeutically induced anti-tumor immunity. An iridium(III) complex (Ir1), containing an N,N-bis(2-chloroethyl)-azane derivate, as an endoplasmic reticulum-localized ICD inducer for non-small cell lung cancer (NSCLC) is reported. The characteristic discharge of damage-associated molecular patterns (DAMPs), that is, cell surface exposure of calreticulin (CRT), extracellular exclusion of high mobility group box 1 (HMGB1), and ATP, were generated by Ir1 in A549 lung cancer cells, accompanied by an increase in endoplasmic reticulum stress and reactive oxygen species (ROS). The vaccination of immunocompetent mice with Ir1-treated dying cells elicited an antitumor CD8+ T cell response and Foxp3+ T cell depletion, which eventually resulted in long-acting anti-tumor immunity by the activation of ICD in lung cancer cells. Ir1 is the first Ir-based complex that is capable of developing an immunomodulatory response by immunogenic cell death.
科研通智能强力驱动
Strongly Powered by AbleSci AI