免疫疗法
医学
CD28
单克隆抗体
抗原
癌症研究
免疫系统
免疫学
彭布罗利珠单抗
抗体
双特异性抗体
CD8型
作者
Janelle Waite,Bei Wang,Lauric Haber,Aynur Hermann,Erica Ullman,Xuan Ye,Drew Dudgeon,Rabih Slim,Dharani K. Ajithdoss,Stephen Godin,Ilyssa Ramos,Qi Wu,Erin Oswald,Patrick Poon,Jacquelynn Golubov,Devon Grote,Jennifer Stella,Arpita Pawashe,Jennifer Finney,Evan Herlihy
标识
DOI:10.1126/scitranslmed.aba2325
摘要
Antibodies cross-linking the CD28 costimulatory pathway and a target antigen on tumors potentiate the effects of checkpoint immunotherapy.
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