大麻
体素
基于体素的形态计量学
心理学
顶叶
额叶
多元分析
枕叶
颞叶
大麻依赖
听力学
神经科学
医学
内科学
精神科
白质
磁共振成像
放射科
癫痫
大麻酚
出处
期刊:Neuroreport
[Ovid Technologies (Wolters Kluwer)]
日期:2020-10-08
卷期号:31 (17): 1236-1241
被引量:4
标识
DOI:10.1097/wnr.0000000000001532
摘要
Recent structural MRI studies on gray matter (GM) volumes using group-level mass-univariate statistical analysis suggest that chronic and heavy cannabis exposure may affect brain region-based morphology. In this prospective study, we use a multivariate pattern analysis approach to investigate the voxel-level change of GM densities in chronic heavy cannabis users. Principal component analysis and linear support vector machine are used in this study, resulting in an 88.1% separation between chronic heavy cannabis users (N = 20) and non-cannabis healthy controls (HCs, N = 22) through leave-one-out cross-validation. The model's discriminative pattern showed that GM density decreases in the part of middle frontal gyrus, inferior frontal gyrus, middle temporal gyrus, inferior temporal gyrus and left occipital lobe in heavy cannabis users with respect to HCs and increases in the part of lentiform nucleus, left cerebellum and right parietal lobe. These results suggest that GM densities alteration has taken place on chronic heavy cannabis users compared with HCs at voxel level.
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