化学
催化作用
镍
酰胺
功能群
群(周期表)
基质(水族馆)
组合化学
硼
还原消去
药物化学
苯
有机化学
海洋学
地质学
聚合物
作者
Rui Pan,Cong Shi,Dongquan Zhang,Yang Tian,Songjin Guo,Hequan Yao,Aijun Lin
出处
期刊:Organic Letters
[American Chemical Society]
日期:2019-11-05
卷期号:21 (22): 8915-8920
被引量:36
标识
DOI:10.1021/acs.orglett.9b03147
摘要
An unprecedented nickel-catalyzed reductive 1,2-dialkynylation of alkenes bearing an 8-aminoquinoline directing group has been developed. This method proceeded through a migratory insertion/reductive-coupling process under mild conditions with a wide substrate scope and good functional group tolerance, providing direct access to the synthetically flexible 1,5-diynes. Moreover, the 1,2-dialkynylation products could be further converted to borate-ester- or azide-functionalized 1,5-dienes, ditriazole, β-diyne primary amide, and trisubstituted benzene.
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