Evaluation of IL‐2, IL‐4, IL‐6, IL‐10, TNF‐α, and IFN‐γ cytokines in HIV/HHV‐8 coinfection

原发性渗出性淋巴瘤 共感染 免疫学 细胞因子 卡波西肉瘤 医学 白细胞介素 肿瘤坏死因子α 免疫病理学 病毒学 干扰素γ 淋巴瘤 干扰素 免疫系统 病毒 人类疱疹病毒
作者
Dayvson Maurício da Silva,Juliana Prado Gonçales,José Valter Joaquim Silva Júnior,Thaísa Regina Rocha Lopes,Luan Araújo Bezerra,Virgínia Maria Barros de Lorena,Maria Rosângela Cunha Duarte Coêlho
出处
期刊:Journal of Medical Virology [Wiley]
卷期号:93 (6): 4033-4037 被引量:8
标识
DOI:10.1002/jmv.26516
摘要

Imbalance in the immune response is one of the main pathogenic mechanisms of diseases related with human immunodeficiency virus (HIV)/human gammaherpesvirus 8 (HHV-8) coinfection, such as Kaposi's sarcoma (KS), primary effusion lymphoma (PEL), multicentric Castleman disease (MCD) and the Kaposi's sarcoma-associated herpesvirus inflammatory cytokine syndrome (KICS). However, significant changes in pro- and anti-inflammatory cytokine levels may be observed in HIV/HHV-8 individuals who are negative for KS, PEL, MCD, and/or KICS. In this study, serum levels of interleukin-2 (IL-2), IL-4, IL-6, IL-10, tumor nucrosis factor α (TNF-α) and interferon γ (IFN-γ) were assessed in 69 HIV and 48 HIV/HHV-8 individuals, all negatives for HHV-8-related diseases. The cytokines were measured by flow cytometry and analyzed by the Mann-Whitney test. The p < .05 and 95% confidence interval were considered in all analyzes. IL-4 (p = .0155), IL-6 (p = .0036), and IL-10 (p = .0036) levels were significantly higher in HIV/HHV-8 patients than in the HIV group. On the other hand, IL-2 (p = .2295), TNF-α (p = .1216) and IFN-γ (p = .1178) did not differ between the groups analyzed. To our knowledge, to date, this is the first report on significant differences in the levels of IL-4 and IL-6 in HIV versus HIV/HHV-8 individuals. Finally, these early findings are important as a prognostic tool and contribute to clarifying the HHV-8-host interaction.
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