Maternal Iron Deficiency Elicits Changes in Placental Development and Alters Fetal Growth Trajectories

胎盘 胎儿 怀孕 血红蛋白 男科 缺铁 子痫前期 概念 贫血 氧气输送 妊娠期 医学 生理学 缺铁性贫血 胎儿生长 生物 内科学 化学 氧气 有机化学 遗传学
作者
Hannah Roberts,Andrew G. Woodman,Stéphane Bourque,Stephen J. Renaud
出处
期刊:The FASEB Journal [Wiley]
卷期号:34 (S1): 1-1
标识
DOI:10.1096/fasebj.2020.34.s1.02821
摘要

Iron is an essential mineral that participates in oxygen transport, DNA synthesis and repair, and as a cofactor for various cellular processes. Iron deficiency (ID) is the most common nutritional deficiency worldwide and pregnant women are one of the populations most at risk. ID during pregnancy poses major health concerns for the developing baby, including fetal growth restriction and long‐term health complications. Maternal ID may indirectly impair fetal growth through changes in the structure and function of the placenta, however, the effect of ID on the placenta is not well understood. Objective This project aims to establish a model of ID in pregnant rats and investigate the resulting changes in placental development and fetal growth. Methods Pregnant Sprague‐Dawley rats were fed either a low iron (10 mg iron/kg) or iron‐replete (37 iron/kg) diet starting two weeks before pregnancy to induce a state of ID anemia alongside respective controls. Detection of sperm in a vaginal lavage was designated gestational day (GD) 0.5. Conceptuses were dissected at either GD 13.5 or GD 18.5. Dam and fetal hemoglobin (Hb) concentration and body weight were measured. Placentas were weighed, cryosectioned and stained with hematoxylin and eosin to assess the cross‐sectional areas of the labyrinth and junctional zones (anatomical units of the rodent placenta). Placental mRNA expression of iron transporters and other nutrient transporters was measured by Clariom S microarray. Results Compared to controls, ID reduced maternal hemoglobin (Hb) throughout pregnancy, including a 44% (P=0.0006) reduction on GD 18.5. Fetal Hb was also reduced in ID on GD 18.5 by 47% (P<0.0001). ID caused a 14% (P=0.03) reduction in total fetal body weight and reduced fetal liver weight by 18% (P=0.003) compared to controls. There was no change in fetal brain, heart or kidney weight. Interestingly, relative placental size was increased in ID by 33% (P=0.0008), including a 27% (P=0.007) increase in junctional zone area and no change in labyrinth zone area. Conclusion Maternal ID was associated with the development of anemia in both moms and fetuses. ID also decreased fetal weight and increased placental growth, specifically in the junctional zone. Significance and Implications Decreased iron availability and oxygen‐carrying capacity in pregnancy may stimulate placental structural changes as a compensatory response to maintain fetal nutrition and oxygenation. Although such adaptations may provide short‐term benefits to the baby, they may ultimately lead to placental insufficiency and failure to meet fetal demands, resulting in fetal growth restriction. Since the placenta forms the interface between a mother and her baby, these modifications may yield new diagnostic indices of fetal distress in ID pregnancies, such as placental size changes that can be detected by ultrasound or post‐partum analysis of placental nutrient transporters and markers of inflammation. Knowledge of such changes may, therefore, lead to earlier interventions and improved fetal outcomes. Support or Funding Information Canadian Institutes of Health Research

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
刚刚
陈什么烨发布了新的文献求助10
1秒前
1秒前
2秒前
情怀应助嘉嘉琦采纳,获得10
2秒前
Ava应助WSGQT采纳,获得10
3秒前
Jiang发布了新的文献求助10
4秒前
超帅听枫完成签到,获得积分20
4秒前
SYLH应助poli采纳,获得10
5秒前
生菜完成签到,获得积分10
5秒前
bxxxxx应助FFF采纳,获得30
5秒前
senhoo完成签到,获得积分10
6秒前
6秒前
JamesPei应助Ana采纳,获得10
6秒前
superbada发布了新的文献求助30
6秒前
希望天下0贩的0应助雪碧采纳,获得10
9秒前
爆米花应助科研通管家采纳,获得10
10秒前
坦率的匪应助科研通管家采纳,获得10
10秒前
10秒前
隐形曼青应助科研通管家采纳,获得10
10秒前
pcr163应助科研通管家采纳,获得80
10秒前
大模型应助科研通管家采纳,获得30
10秒前
Jasper应助科研通管家采纳,获得10
10秒前
大个应助科研通管家采纳,获得10
10秒前
科研通AI5应助舒服的乐曲采纳,获得10
10秒前
传奇3应助科研通管家采纳,获得10
10秒前
坦率的匪应助科研通管家采纳,获得10
10秒前
汉堡包应助科研通管家采纳,获得10
10秒前
10秒前
坦率的匪应助科研通管家采纳,获得10
10秒前
10秒前
quhayley应助科研通管家采纳,获得10
10秒前
要减肥岩应助科研通管家采纳,获得10
11秒前
彭于彦祖应助培爷采纳,获得30
11秒前
Mininine完成签到,获得积分10
11秒前
11秒前
Akim应助科研通管家采纳,获得10
11秒前
quhayley应助科研通管家采纳,获得10
11秒前
LUJyyyy完成签到,获得积分10
11秒前
SciGPT应助科研通管家采纳,获得10
11秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
‘Unruly’ Children: Historical Fieldnotes and Learning Morality in a Taiwan Village (New Departures in Anthropology) 400
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3988732
求助须知:如何正确求助?哪些是违规求助? 3531027
关于积分的说明 11252281
捐赠科研通 3269732
什么是DOI,文献DOI怎么找? 1804764
邀请新用户注册赠送积分活动 881869
科研通“疑难数据库(出版商)”最低求助积分说明 809021