Identification of neurobehavioural symptom groups based on shared brain mechanisms

神经影像学 精神病理学 焦虑 心理学 萧条(经济学) 模式 临床心理学 神经功能成像 大脑结构与功能 心理干预 精神科 社会科学 宏观经济学 社会学 经济
作者
Alex Ing,Philipp G. Sämann,Congying Chu,Nicole Tay,Francesca Biondo,Guillaume Robert,Tianye Jia,Thomas Wolfers,Sylvane Desrivières,Tobias Banaschewski,Arun L.W. Bokde,Uli Bromberg,Christian Büchel,Patricia Conrod,Tahmine Fadai,Herta Flor,Vincent Frouin,Hugh Garavan,Philip A. Spechler,Penny Gowland
出处
期刊:Nature Human Behaviour [Springer Nature]
卷期号:3 (12): 1306-1318 被引量:52
标识
DOI:10.1038/s41562-019-0738-8
摘要

Most psychopathological disorders develop in adolescence. The biological basis for this development is poorly understood. To enhance diagnostic characterization and develop improved targeted interventions, it is critical to identify behavioural symptom groups that share neural substrates. We ran analyses to find relationships between behavioural symptoms and neuroimaging measures of brain structure and function in adolescence. We found two symptom groups, consisting of anxiety/depression and executive dysfunction symptoms, respectively, that correlated with distinct sets of brain regions and inter-regional connections, measured by structural and functional neuroimaging modalities. We found that the neural correlates of these symptom groups were present before behavioural symptoms had developed. These neural correlates showed case–control differences in corresponding psychiatric disorders, depression and attention deficit hyperactivity disorder in independent clinical samples. By characterizing behavioural symptom groups based on shared neural mechanisms, our results provide a framework for developing a classification system for psychiatric illness that is based on quantitative neurobehavioural measures. Ing et al. develop a method of establishing direct relationships between psychiatric symptoms and neuroimaging measures of brain structure and function and use it to stratify adolescent psychopathology on the basis of underlying biology. They replicate their results in independent clinical samples.
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