医学
脉冲波速
内科学
荟萃分析
心脏病学
亚临床感染
内膜中层厚度
颈动脉
血压
作者
Marinos Kosmopoulos,Martina Chiriacò,Κimon Stamatelopoulos,Konstantinos Tsioufis,Pier Giorgio Masci,Christos Kontogiannis,Alessandro Mengozzi,Nicola Riccardo Pugliese,Stefano Taddei,Agostino Virdis,Stefano Masi,Georgios Georgiopoulos
标识
DOI:10.1016/j.mad.2021.111604
摘要
Accelerated biological aging contributes to the evolution of cardiovascular disease. However, its influence on subclinical organ damage remains unclear. Leukocyte telomere length (LTL) is emerging as a marker of biological cardiovascular aging. We performed a systematic review and meta-analysis to assess the association between LTL and measures of end-organ damage. PubMed, Medline, Embase, Cinahl Plus, ClinicalTrials.gov, and grey literature databases were searched for studies that assessed the association of LTL with arterial pulse wave velocity (aPWV), carotid intima-media thickness (cIMT), left ventricular mass (LVM or LVMI), renal outcomes, coronary artery calcium (CAC) and presence of carotid plaques. In a sample of 7256 patients, we found that cIMT (pooled correlation coefficient (r) = -0.249; 95 %CI -0.37, -0.128) and aPWV (pooled r = -0.194; 95 % CI -0.290, -0.100) inversely correlate with LTL. Compared to aPWV, cIMT had a stronger correlation with LTL. Patients without carotid plaques had longer telomeres than patients with carotid plaques. Quantitative analyses documented LTL association with renal outcomes and CAC, but not with LVM/LVMI. Among measures of end-organ damage, cIMT and aPWV provide the most accurate information on the contribution of biological aging to the process of vascular remodeling/damage.
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