病毒学
病毒
生物
基因座(遗传学)
等位基因
甲型流感病毒
聚合酶链反应
H5N1亚型流感病毒
基因
遗传学
大流行
毒力
传染病(医学专业)
疾病
2019年冠状病毒病(COVID-19)
医学
病理
作者
Yongkun Chen,Laura Graf,Tao Chen,Qijun Liao,Tian Bai,Philipp P. Petric,Wenfei Zhu,Lei Yang,Jie Dong,Jian Lü,Ying Chen,Juan Shen,Otto Haller,Peter Staeheli,Georg Kochs,Dayang Wang,Martin Schwemmle,Yuelong Shu
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2021-08-20
卷期号:373 (6557): 918-922
被引量:43
标识
DOI:10.1126/science.abg5953
摘要
Poultry passport to pandemic What conditions are required to nurture the seeds of a pandemic? The avian influenza virus H7N9 rarely spills over into humans, but when it does, mortality exceeds 30%, far in excess of that of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Chen et al . used whole-genome sequencing to investigate the contribution of rare mutations among poultry workers who can be exposed to high levels of H7N9. Multiple defective single-nucleotide variants in the myxovirus resistance Mx1 locus were prevalent in H7N9 patients. In vitro infection experiments and influenza polymerase activity assays showed that 14 of the 17 MxA protein variants had no antiviral activity. Thus, individuals with such genetic vulnerabilities, when exposed to high virus loads, may act as crucibles for transmission of virulent new influenza subtypes. —CA
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