金丝桃素
程序性细胞死亡
细胞凋亡
活力测定
化学
细胞生长
细胞
光动力疗法
光敏剂
癌症研究
光毒性
医学
药理学
体外
光化学
生物化学
有机化学
作者
Gislaine Patricia Andrade,Thaiza. Ferreira. Menegassi de Souza,Giselle Cerchiaro,Maria Aparecida da Silva Pinhal,Anderson Orzari Ribeiro,Manoel Joâo Batista Castello Girão
标识
DOI:10.1016/j.pdpdt.2021.102343
摘要
Hypericin is considered a potent photosensitizer for use in antitumor and antimicrobial photodynamic therapy (PDT). This review presents the primary biological results obtained with hypericin in photodynamic therapy applications, such as photodynamic cancer treatment, photoinactivation of microorganisms (PDI), tissue scarring, and photo diagnosis. We present a compilation of in vitro results that have been published thus far; for these studies, we highlight the hypericin concentration, light dose, and other experimental conditions to evaluate the efficiency of photodynamic treatment like cell death, cell viability, or cell proliferation. The results indicate that different hypericin phototoxicity levels can be observed according to the specific light dose and concentration. Furthermore, it was shown that cellular localization and cell death mechanisms (apoptosis and necrosis) are dependent on the cell type.
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