MUC1号
卵巢癌
癌症研究
蛋白激酶B
癌症
跨膜蛋白
信号转导
生物
医学
肿瘤科
内科学
细胞生物学
受体
作者
Qingxia Ma,Jingyi Song,Shuo Wang,Ningning He
标识
DOI:10.1016/j.prp.2021.153509
摘要
MUC1, a type I transmembrane glycoprotein, mediates tumor growth and cellular differentiation in various types of cancers. However, the mechanism of MUCI in ovarian cancer has not been fully clarified. In our study, we have observed that MUC1 can play a crucial role in the development and progression of ovarian cancer and act as a predictive marker. We also found that MUC1 could increase the expression of EGFR, and MUC1-EGFR co-administration could promote the cellular growth via the AKT pathway. Taxol is an important drug for treating ovarian cancer, which can prevent cancer recurrence and reduce mortality. Our data have collectively reflected that Taxol can prevent ovarian cancer with abnormal expression of MUC1.
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