炎症
光老化
卵泡抑素
巨噬细胞极化
富血小板血浆
伤口愈合
癌症研究
医学
病理
免疫学
化学
巨噬细胞
内分泌学
血小板
皮肤病科
生物化学
体外
作者
Gajin Park,Wen Qian,Mei‐Jie Zhang,Yi-He Chen,Liwen Ma,Ni Zeng,Qian Lu,Yueyue Li,Weiwei Ma,Xufeng Yin,Bingrong Zhou,Dan Luo
出处
期刊:Bioengineered
[Informa]
日期:2021-01-01
卷期号:12 (1): 3125-3136
被引量:9
标识
DOI:10.1080/21655979.2021.1944026
摘要
Ultraviolet B (UVB) is one of the most common exogenous factors in skin aging, especially photoaging. Once a large amount of UVB accumulates within a short period of time, skin tissue can become inflamed. It has also been found in clinics that platelet-rich plasma (PRP) can promote wound repair; therefore, the aim of this study was to identify the mechanism by which PRP repairs UVB-induced skin photodamage. We used PRP of Sprague-Dawley rats with the two-spin technique in the established acute UVB radiation photodamage model and harvested the corresponding skin after 1, 7, and 28 d. Hematoxylin and eosin staining was used to observe tissue inflammation. We found that PRP reduces inflammation in the early stages of UVB-induced acute skin damage, and then promotes the proliferation of collagen in the middle and late stages. Moreover, PRP can stimulate Act A and M1 polarization in the early stage, while inhibiting activin A (Act A) and inducing M2 polarization in the middle and late stages. In conclusion, this study demonstrates that PRP plays an important regulatory role in helping reduce UVB-induced acute skin tissue inflammation by adjusting macrophage polarization, which alleviates skin inflammation and stimulates collagen regeneration.
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