等离子体子
纳米技术
石墨烯
纳米颗粒
量子点
拉曼光谱
纳米材料
拉曼散射
材料科学
细胞内
生物分析
催化作用
基质(水族馆)
化学
光电子学
地质学
物理
光学
海洋学
生物化学
作者
Jing Jin,Wei Song,Jiaqi Wang,Linjia Li,Yu Tian,Shoujun Zhu,Yuping Zhang,Shuping Xu,Bai Yang,Bing Zhao
标识
DOI:10.1016/j.cej.2021.132687
摘要
The small-sized plasmonic nanoparticles are easily internalized by cells and organelles, but usually possess poor surface-enhanced Raman scattering (SERS) activity, restricting their promising applications for intracellular SERS analysis. To break the current bottleneck of intracellular SERS application, herein, a uniform and small-sized (ca. 10 nm) core–shell Ag/oxidized graphene quantum dots (o-GQDs) nanohybrids have been prepared. The Ag/o-GQDs inherit unique features with parallel-interlaced stacking of o-GQDs as capping agent, possess the increasing and broadening plasmon adsorption and display a unique edge state charge transfer (CT) resonance in the long-wavelength region of visible light, enabling the enhanced electromagnetic (EM) and CT effect for superior SERS sensitivity at lower energy. Further, the Ag/o-GQDs demonstrate excellent biocompatibility and highly efficient nanozymatically catalytic activity, which are first put forward to integrate efficient SERS with Ag/o-GQDs nanozyme to catalyze peroxidase-like reaction for accurate sensing of the intracellular H2O2 at the subcellular level. Moreover, the Ag/o-GQDs nanozyme-catalyzed reactive oxygen species (ROS) generation and the cancer cell multisubcellular-targeting capability provide a promising strategy for the synergistically catalytic therapy specifically toward tumors. This study illustrates a significant route to design an efficient small-sized noble metal/carbon nanozymatic SERS substrate, and demonstrates an exciting potential for ultrasensitive SERS bioanalysis at the subcellular level.
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