化学
整体
两亲性
有机化学
羧酸
催化作用
酰化
色谱法
共聚物
聚合物
作者
Fumika Wakayama,Ryo Ito,Kwihwan Park,Moeka Ishida,Yutaro Yamada,Shuta Ichihara,Hitoshi Takada,Shinji Nakamura,Ayumu Kato,Tsuyoshi Yamada,Hironao Sajiki,Yasunari Monguchi
标识
DOI:10.1246/bcsj.20210266
摘要
Abstract We have developed a method for the esterification of carboxylic acids with alcohols using amphipathic, monolithic-resin bearing sulfonic acid moieties as cation exchange functions (monolith-SO3H). Monolith-SO3H efficiently catalyzed the esterification of aromatic and aliphatic carboxylic acids with various primary and secondary alcohols (1.5–5.0 equiv) in toluene at 60–80 °C without the need to remove water generated during the reaction. The amphipathic property of monolith-SO3H facilitates dehydration due to its capacity for water absorption. This reaction was also applicable to thioesterification, wherein the corresponding thioesters were obtained in excellent yield using only 2.0 equiv of thiol in toluene, although heating at 120 °C was required. Moreover, monolith-SO3H was separable from the reaction mixtures by simple filtration and reused for at least five runs without decreasing the catalytic activity.
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