Cognitive Impairment in Survivors of Pediatric Extracranial Solid Tumors and Lymphomas

Article Tools REVIEW ARTICLES Neurocognitive Outcomes in Survivors of Pediatric Cancer Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.20.02358 Journal of Clinical Oncology - published online before print April 22, 2021 PMID: 33886354 Cognitive Impairment in Survivors of Pediatric Extracranial Solid Tumors and Lymphomas Rebecca Foster , PhD1,2xRebecca FosterSearch for articles by this author; Daniel J. Zheng, MD, MHS3xDaniel J. ZhengSearch for articles by this author; Kelli L. Netson-Amore , PhD4xKelli L. Netson-AmoreSearch for articles by this author; and Nina S. Kadan-Lottick , MD, MSPH5xNina S. Kadan-LottickSearch for articles by this author Show More 1St Louis Children's Hospital, St Louis, MO2Washington University, St Louis, MO3Boston Children's Hospital, Boston, MA4University of Kansas School of Medicine-Wichita, Wichita, KS5Yale University School of Medicine and Yale Cancer Center, New Haven, CT https://doi.org/10.1200/JCO.20.02358 First Page Full Text PDF Figures and Tables © 2021 by American Society of Clinical OncologyCONTEXTKey ObjectiveAre cognitive outcomes impaired in survivors of childhood extracranial solid tumors and lymphomas? In our critical review of the literature, we explored cognitive functioning after specific extracranial solid tumor and lymphoma diagnoses, discussed possible associated risk factors, highlighted research gaps, and provided clinical guidance for affected survivors.Knowledge GeneratedExisting studies suggest that survivors of osteosarcoma, neuroblastoma, Wilms tumor, non-Hodgkin lymphoma, Hodgkin lymphoma, and Langerhans cell histiocytosis have increased risk of cognitive impairment. Co-morbid health conditions were frequently associated with cognition.RelevanceGiven the older age at diagnosis of many childhood extracranial solid tumors and lymphomas as well as toxicities associated with certain therapies, patients may benefit from vocational services, occupational therapy, physical therapy, and/or hearing or visual rehabilitation in addition to surveillance for cognitive difficulties.AUTHOR CONTRIBUTIONSConception and design: Rebecca Foster, Kelli L. Netson-Amore, Nina S. Kadan-LottickAdministrative support: Nina S. Kadan-LottickCollection and assembly of data: Daniel J. Zheng, Kelli L. Netson-Amore, Nina S. Kadan-LottickData analysis and interpretation: Daniel J. ZhengManuscript writing: All authorsFinal approval of manuscript: All authorsAccountable for all aspects of the work: All authorsAUTHORS' DISCLOSURES OF POTENTIAL CONFLICTS OF INTERESTCognitive Impairment in Survivors of Pediatric Extracranial Solid Tumors and LymphomasThe following represents disclosure information provided by authors of this manuscript. All relationships are considered compensated unless otherwise noted. Relationships are self-held unless noted. I = Immediate Family Member, Inst = My Institution. Relationships may not relate to the subject matter of this manuscript. For more information about ASCO's conflict of interest policy, please refer to www.asco.org/rwc or ascopubs.org/jco/authors/author-center.Open Payments is a public database containing information reported by companies about payments made to US-licensed physicians (Open Payments).Nina S. Kadan-LottickHonoraria: Medtronic, Boston ScientificConsulting or Advisory Role: Medtronic, Boston ScientificSpeakers' Bureau: Medtronic, Boston ScientificNo other potential conflicts of interest were reported.