A Mouse Model of Helicobacter pylori Infection

Infection Infections with Helicobacter pylori (H. pylori) Helicobacter pylori (H. pylori) is of great distress because of its vital role in the pathogenesis of chronic gastritisGastritis, peptic ulcersPeptic ulcers, and in the multi-step carcinogenic process of gastric cancerGastric cancer. The increasing antibiotic resistanceAntibiotic resistance pattern of H. pylori worldwide has prompted the World Health Organization to put this organism in the priority pathogens list. To study the disease biology, evaluation of drugs, treatment Treatments outcome and to come up with probable vaccination strategies, competent animal models that reproduce the signature of human infection Infections are essential. Initial reports about animal colonizationColonization with H. pylori have shown significant heterogeneity, to such an extent that Barry Marshall, Nobel laureate for the discovery of H. pylori , infected himself with the bacterium Bacteria to show its involvement in acute gastric illness. A paradigm-shift discovery of the H. pylori mouse-adapted strain SS1 has opened the avenues of research regarding the organism and its pathogenicity. Although the mouse modelMouse models of H. pylori infection Infections is being utilized all over the world, there are certain issues that need awareness and specific information to achieve successful, consistent colonizationColonization with symptoms resembling human. This chapter details an established and reliable protocol for the development of a competent mouse modelMouse models for H. pylori infection Infections leading to various gastro-intestinal diseases.