Autophagy in major human diseases

Review30 August 2021Open Access Autophagy in major human diseases Daniel J Klionsky Daniel J Klionsky orcid.org/0000-0002-7828-8118 Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA Search for more papers by this author Giulia Petroni Giulia Petroni Department of Radiation Oncology, Weill Cornell Medical College, New York, NY, USA Search for more papers by this author Ravi K Amaravadi Ravi K Amaravadi Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA Search for more papers by this author Eric H Baehrecke Eric H Baehrecke Department of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, Worcester, MA, USA Search for more papers by this author Andrea Ballabio Andrea Ballabio orcid.org/0000-0003-1381-4604 Telethon Institute of Genetics and Medicine, Pozzuoli, Italy Department of Translational Medical Sciences, Section of Pediatrics, Federico II University, Naples, Italy Department of Molecular and Human Genetics, Baylor College of Medicine, and Jan and Dan Duncan Neurological Research Institute, Texas Children Hospital, Houston, TX, USA Search for more papers by this author Patricia Boya Patricia Boya orcid.org/0000-0003-3045-951X Margarita Salas Center for Biological Research, Spanish National Research Council, Madrid, Spain Search for more papers by this author José Manuel Bravo-San Pedro José Manuel Bravo-San Pedro Faculty of Medicine, Department Section of Physiology, Complutense University of Madrid, Madrid, Spain Center for Networked Biomedical Research in Neurodegenerative Diseases (CIBERNED), Madrid, Spain Search for more papers by this author Ken Cadwell Ken Cadwell Kimmel Center for Biology and Medicine at the Skirball Institute, New York University Grossman School of Medicine, New York, NY, USA Department of Microbiology, New York University Grossman School of Medicine, New York, NY, USA Division of Gastroenterology and Hepatology, Department of Medicine, New York University Langone Health, New York, NY, USA Search for more papers by this author Francesco Cecconi Francesco Cecconi orcid.org/0000-0002-5614-4359 Cell Stress and Survival Unit, Center for Autophagy, Recycling and Disease (CARD), Danish Cancer Society Research Center, Copenhagen, Denmark Department of Pediatric Onco-Hematology and Cell and Gene Therapy, IRCCS Bambino Gesù Children's Hospital, Rome, Italy Department of Biology, University of Rome ‘Tor Vergata’, Rome, Italy Search for more papers by this author Augustine M K Choi Augustine M K Choi Division of Pulmonary and Critical Care Medicine, Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medicine, New York, NY, USA New York-Presbyterian Hospital, Weill Cornell Medicine, New York, NY, USA Search for more papers by this author Mary E Choi Mary E Choi New York-Presbyterian Hospital, Weill Cornell Medicine, New York, NY, USA Division of Nephrology and Hypertension, Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medicine, New York, NY, USA Search for more papers by this author Charleen T Chu Charleen T Chu orcid.org/0000-0002-5052-8271 Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA Search for more papers by this author Patrice Codogno Patrice Codogno orcid.org/0000-0002-5492-3180 Institut Necker-Enfants Malades, INSERM U1151-CNRS UMR 8253, Paris, France Université de Paris, Paris, France Search for more papers by this author Maria Isabel Colombo Maria Isabel Colombo Laboratorio de Mecanismos Moleculares Implicados en el Tráfico Vesicular y la Autofagia-Instituto de Histología y Embriología (IHEM)-Universidad Nacional de Cuyo, CONICET- Facultad de Ciencias Médicas, Mendoza, Argentina Search for more papers by this author Ana Maria Cuervo Ana Maria Cuervo orcid.org/0000-0002-0771-700X Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY, USA Institute for Aging Studies, Albert Einstein College of Medicine, Bronx, NY, USA Search for more papers by this author Vojo Deretic Vojo Deretic Autophagy Inflammation and Metabolism (AIM, Center of Biomedical Research Excellence, University of New Mexico Health Sciences Center, Albuquerque, NM, USA Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, Albuquerque, NM, USA Search for more papers by this author Ivan Dikic Ivan Dikic orcid.org/0000-0001-8156-9511 Institute of Biochemistry II, School of Medicine, Goethe University, Frankfurt, Frankfurt am Main, Germany Buchmann Institute for Molecular Life Sciences, Goethe University, Frankfurt, Frankfurt am Main, Germany Search for more papers by this author Zvulun Elazar Zvulun Elazar Department of Biomolecular Sciences, The Weizmann Institute of Science, Rehovot, Israel Search for more papers by this author Eeva-Liisa Eskelinen Eeva-Liisa Eskelinen Institute of Biomedicine, University of Turku, Turku, Finland Search for more papers by this author Gian Maria Fimia Gian Maria Fimia orcid.org/0000-0003-4438-3325 Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy Department of Epidemiology, Preclinical Research, and Advanced Diagnostics, National Institute for Infectious Diseases ‘L. Spallanzani’ IRCCS, Rome, Italy Search for more papers by this author David A Gewirtz David A Gewirtz orcid.org/0000-0003-0437-4934 Department of Pharmacology and Toxicology, School of Medicine, Virginia Commonwealth University, Richmond, VA, USA Search for more papers by this author Douglas R Green Douglas R Green Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA Search for more papers by this author Malene Hansen Malene Hansen Sanford Burnham Prebys Medical Discovery Institute, Program of Development, Aging, and Regeneration, La Jolla, CA, USA Search for more papers by this author Marja Jäättelä Marja Jäättelä orcid.org/0000-0001-5950-7111 Cell Death and Metabolism, Center for Autophagy, Recycling & Disease, Danish Cancer Society Research Center, Copenhagen, Denmark Department of Cellular and Molecular Medicine, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark Search for more papers by this author Terje Johansen Terje Johansen orcid.org/0000-0003-1451-9578 Department of Medical Biology, Molecular Cancer Research Group, University of Tromsø—The Arctic University of Norway, Tromsø, Norway Search for more papers by this author Gábor Juhász Gábor Juhász Institute of Genetics, Biological Research Center, Szeged, Hungary Department of Anatomy, Cell and Developmental Biology, Eötvös Loránd University, Budapest, Hungary Search for more papers by this author Vassiliki Karantza Vassiliki Karantza Merck & Co., Inc., Kenilworth, NJ, USA Search for more papers by this author Claudine Kraft Claudine Kraft orcid.org/0000-0002-3324-4701 Institute of Biochemistry and Molecular Biology, ZBMZ, Faculty of Medicine, University of Freiburg, Freiburg, Germany CIBSS - Centre for Integrative Biological Signalling Studies, University of Freiburg, Freiburg, Germany Search for more papers by this author Guido Kroemer Guido Kroemer orcid.org/0000-0002-9334-4405 Centre de Recherche des Cordeliers, Equipe Labellisée par la Ligue Contre le Cancer, Université de Paris, Sorbonne Université, Inserm U1138, Institut Universitaire de France, Paris, France Metabolomics and Cell Biology Platforms, Institut Gustave Roussy, Villejuif, France Pôle de Biologie, Hôpital Européen Georges Pompidou, AP-HP, Paris, France Suzhou Institute for Systems Medicine, Chinese Academy of Medical Sciences, Suzhou, China Karolinska Institute, Department of Women's and Children's Health, Karolinska University Hospital, Stockholm, Sweden Search for more papers by this author Nicholas T Ktistakis Nicholas T Ktistakis Signalling Programme, Babraham Institute, Cambridge, UK Search for more papers by this author Sharad Kumar Sharad Kumar orcid.org/0000-0001-7126-9814 Centre for Cancer Biology, University of South Australia, Adelaide, SA, Australia Faculty of Health and Medical Sciences, University of Adelaide, Adelaide, SA, Australia Search for more papers by this author Carlos Lopez-Otin Carlos Lopez-Otin orcid.org/0000-0001-6964-1904 Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Instituto Universitario de Oncología del Principado de Asturias (IUOPA), Universidad de Oviedo, Oviedo, Spain Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain Search for more papers by this author Kay F Macleod Kay F Macleod The Ben May Department for Cancer Research, The Gordon Center for Integrative Sciences, W-338, The University of Chicago, Chicago, IL, USA The University of Chicago, Chicago, IL, USA Search for more papers by this author Frank Madeo Frank Madeo Institute of Molecular Biosciences, NAWI Graz, University of Graz, Graz, Austria BioTechMed-Graz, Graz, Austria Field of Excellence BioHealth – University of Graz, Graz, Austria Search for more papers by this author Jennifer Martinez Jennifer Martinez Immunity, Inflammation and Disease Laboratory, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC, USA Search for more papers by this author Alicia Meléndez Alicia Meléndez Biology Department, Queens College, City University of New York, Flushing, NY, USA The Graduate Center Biology and Biochemistry PhD Programs of the City University of New York, New York, NY, USA Search for more papers by this author Noboru Mizushima Noboru Mizushima orcid.org/0000-0002-6258-6444 Department of Biochemistry and Molecular Biology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan Search for more papers by this author Christian Münz Christian Münz orcid.org/0000-0001-6419-1940 Viral Immunobiology, Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland Search for more papers by this author Josef M Penninger Josef M Penninger Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA), Vienna BioCenter (VBC), Vienna, Austria Department of Medical Genetics, Life Sciences Institute, University of British Columbia, Vancouver, BC, Canada Search for more papers by this author Rushika M Perera Rushika M Perera orcid.org/0000-0003-2435-2273 Department of Anatomy, University of California, San Francisco, San Francisco, CA, USA Department of Pathology, University of California, San Francisco, San Francisco, CA, USA Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, USA Search for more papers by this author Mauro Piacentini Mauro Piacentini orcid.org/0000-0003-2919-1296 Department of Biology, University of Rome “Tor Vergata”, Rome, Italy Laboratory of Molecular Medicine, Institute of Cytology Russian Academy of Science, Saint Petersburg, Russia Search for more papers by this author Fulvio Reggiori Fulvio Reggiori orcid.org/0000-0003-2652-2686 Department of Biomedical Sciences of Cells & Systems, Molecular Cell Biology Section, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands Search for more papers by this author David C Rubinsztein David C Rubinsztein Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK UK Dementia Research Institute, University of Cambridge, Cambridge, UK Search for more papers by this author Kevin M Ryan Kevin M Ryan Cancer Research UK Beatson Institute, Glasgow, UK Institute of Cancer Sciences, University of Glasgow, Glasgow, UK Search for more papers by this author Junichi Sadoshima Junichi Sadoshima Department of Cell Biology and Molecular Medicine, Cardiovascular Research Institute, Rutgers New Jersey Medical School, Newark, NJ, USA Search for more papers by this author Laura Santambrogio Laura Santambrogio Department of Radiation Oncology, Weill Cornell Medical College, New York, NY, USA Sandra and Edward Meyer Cancer Center, New York, NY, USA Caryl and Israel Englander Institute for Precision Medicine, New York, NY, USA Search for more papers by this author Luca Scorrano Luca Scorrano orcid.org/0000-0002-8515-8928 Istituto Veneto di Medicina Molecolare, Padova, Italy Department of Biology, University of Padova, Padova, Italy Search for more papers by this author Hans-Uwe Simon Hans-Uwe Simon Institute of Pharmacology, University of Bern, Bern, Switzerland Department of Clinical Immunology and Allergology, Sechenov University, Moscow, Russia Laboratory of Molecular Immunology, Institute of Fundamental Medicine and Biology, Kazan Federal University, Kazan, Russia Search for more papers by this author Anna Katharina Simon Anna Katharina Simon The Kennedy Institute of Rheumatology, NDORMS, University of Oxford, Oxford, UK Search for more papers by this author Anne Simonsen Anne Simonsen orcid.org/0000-0003-4711-7057 Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway Centre for Cancer Cell Reprogramming, Institute of Clinical Medicine, University of Oslo, Oslo, Norway Department of Molecular Cell Biology, Institute for Cancer Research, Oslo University Hospital Montebello, Oslo, Norway Search for more papers by this author Alexandra Stolz Alexandra Stolz orcid.org/0000-0002-3340-439X Institute of Biochemistry II, School of Medicine, Goethe University, Frankfurt, Frankfurt am Main, Germany Buchmann Institute for Molecular Life Sciences, Goethe University, Frankfurt, Frankfurt am Main, Germany Search for more papers by this author Nektarios Tavernarakis Nektarios Tavernarakis orcid.org/0000-0002-5253-1466 Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas, Heraklion, Crete, Greece Department of Basic Sciences, School of Medicine, University of Crete, Heraklion, Crete, Greece Search for more papers by this author Sharon A Tooze Sharon A Tooze orcid.org/0000-0002-2182-3116 Molecular Cell Biology of Autophagy, The Francis Crick Institute, London, UK Search for more papers by this author Tamotsu Yoshimori Tamotsu Yoshimori orcid.org/0000-0001-9787-3788 Department of Genetics, Graduate School of Medicine, Osaka University, Suita, Japan Department of Intracellular Membrane Dynamics, Graduate School of Frontier Biosciences, Osaka University, Suita, Japan Integrated Frontier Research for Medical Science Division, Institute for Open and Transdisciplinary Research Initiatives (OTRI), Osaka University, Suita, Japan Search for more papers by this author Junying Yuan Junying Yuan Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China Department of Cell Biology, Harvard Medical School, Boston, MA, USA Search for more papers by this author Zhenyu Yue Zhenyu Yue Department of Neurology, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA Search for more papers by this author Qing Zhong Qing Zhong orcid.org/0000-0001-6979-955X Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Department of Pathophysiology, Shanghai Jiao Tong University School of Medicine (SJTU-SM), Shanghai, China Search for more papers by this author Lorenzo Galluzzi Corresponding Author Lorenzo Galluzzi [email protected] orcid.org/0000-0003-2257-8500 Department of Radiation Oncology, Weill Cornell Medical College, New York, NY, USA Sandra and Edward Meyer Cancer Center, New York, NY, USA Caryl and Israel Englander Institute for Precision Medicine, New York, NY, USA Department of Dermatology, Yale School of Medicine, New Haven, CT, USA Université de Paris, Paris, France Search for more papers by this author Federico Pietrocola Corresponding Author Federico Pietrocola [email protected] orcid.org/0000-0002-2930-234X Department of Biosciences and Nutrition, Karolinska Institute, Huddinge, Sweden Search for more papers by this author Daniel J Klionsky Daniel J Klionsky orcid.org/0000-0002-7828-8118 Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA Search for more papers by this author Giulia Petroni Giulia Petroni Department of Radiation Oncology, Weill Cornell Medical College, New York, NY, USA Search for more papers by this author Ravi K Amaravadi Ravi K Amaravadi Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA Search for more papers by this author Eric H Baehrecke Eric H Baehrecke Department of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, Worcester, MA, USA Search for more papers by this author Andrea Ballabio Andrea Ballabio orcid.org/0000-0003-1381-4604 Telethon Institute of Genetics and Medicine, Pozzuoli, Italy Department of Translational Medical Sciences, Section of Pediatrics, Federico II University, Naples, Italy Department of Molecular and Human Genetics, Baylor College of Medicine, and Jan and Dan Duncan Neurological Research Institute, Texas Children Hospital, Houston, TX, USA Search for more papers by this author Patricia Boya Patricia Boya orcid.org/0000-0003-3045-951X Margarita Salas Center for Biological Research, Spanish National Research Council, Madrid, Spain Search for more papers by this author José Manuel Bravo-San Pedro José Manuel Bravo-San Pedro Faculty of Medicine, Department Section of Physiology, Complutense University of Madrid, Madrid, Spain Center for Networked Biomedical Research in Neurodegenerative Diseases (CIBERNED), Madrid, Spain Search for more papers by this author Ken Cadwell Ken Cadwell Kimmel Center for Biology and Medicine at the Skirball Institute, New York University Grossman School of Medicine, New York, NY, USA Department of Microbiology, New York University Grossman School of Medicine, New York, NY, USA Division of Gastroenterology and Hepatology, Department of Medicine, New York University Langone Health, New York, NY, USA Search for more papers by this author Francesco Cecconi Francesco Cecconi orcid.org/0000-0002-5614-4359 Cell Stress and Survival Unit, Center for Autophagy, Recycling and Disease (CARD), Danish Cancer Society Research Center, Copenhagen, Denmark Department of Pediatric Onco-Hematology and Cell and Gene Therapy, IRCCS Bambino Gesù Children's Hospital, Rome, Italy Department of Biology, University of Rome ‘Tor Vergata’, Rome, Italy Search for more papers by this author Augustine M K Choi Augustine M K Choi Division of Pulmonary and Critical Care Medicine, Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medicine, New York, NY, USA New York-Presbyterian Hospital, Weill Cornell Medicine, New York, NY, USA Search for more papers by this author Mary E Choi Mary E Choi New York-Presbyterian Hospital, Weill Cornell Medicine, New York, NY, USA Division of Nephrology and Hypertension, Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medicine, New York, NY, USA Search for more papers by this author Charleen T Chu Charleen T Chu orcid.org/0000-0002-5052-8271 Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA Search for more papers by this author Patrice Codogno Patrice Codogno orcid.org/0000-0002-5492-3180 Institut Necker-Enfants Malades, INSERM U1151-CNRS UMR 8253, Paris, France Université de Paris, Paris, France Search for more papers by this author Maria Isabel Colombo Maria Isabel Colombo Laboratorio de Mecanismos Moleculares Implicados en el Tráfico Vesicular y la Autofagia-Instituto de Histología y Embriología (IHEM)-Universidad Nacional de Cuyo, CONICET- Facultad de Ciencias Médicas, Mendoza, Argentina Search for more papers by this author Ana Maria Cuervo Ana Maria Cuervo orcid.org/0000-0002-0771-700X Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY, USA Institute for Aging Studies, Albert Einstein College of Medicine, Bronx, NY, USA Search for more papers by this author Vojo Deretic Vojo Deretic Autophagy Inflammation and Metabolism (AIM, Center of Biomedical Research Excellence, University of New Mexico Health Sciences Center, Albuquerque, NM, USA Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, Albuquerque, NM, USA Search for more papers by this author Ivan Dikic Ivan Dikic orcid.org/0000-0001-8156-9511 Institute of Biochemistry II, School of Medicine, Goethe University, Frankfurt, Frankfurt am Main, Germany Buchmann Institute for Molecular Life Sciences, Goethe University, Frankfurt, Frankfurt am Main, Germany Search for more papers by this author Zvulun Elazar Zvulun Elazar Department of Biomolecular Sciences, The Weizmann Institute of Science, Rehovot, Israel Search for more papers by this author Eeva-Liisa Eskelinen Eeva-Liisa Eskelinen Institute of Biomedicine, University of Turku, Turku, Finland Search for more papers by this author Gian Maria Fimia Gian Maria Fimia orcid.org/0000-0003-4438-3325 Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy Department of Epidemiology, Preclinical Research, and Advanced Diagnostics, National Institute for Infectious Diseases ‘L. Spallanzani’ IRCCS, Rome, Italy Search for more papers by this author David A Gewirtz David A Gewirtz orcid.org/0000-0003-0437-4934 Department of Pharmacology and Toxicology, School of Medicine, Virginia Commonwealth University, Richmond, VA, USA Search for more papers by this author Douglas R Green Douglas R Green Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA Search for more papers by this author Malene Hansen Malene Hansen Sanford Burnham Prebys Medical Discovery Institute, Program of Development, Aging, and Regeneration, La Jolla, CA, USA Search for more papers by this author Marja Jäättelä Marja Jäättelä orcid.org/0000-0001-5950-7111 Cell Death and Metabolism, Center for Autophagy, Recycling & Disease, Danish Cancer Society Research Center, Copenhagen, Denmark Department of Cellular and Molecular Medicine, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark Search for more papers by this author Terje Johansen Terje Johansen orcid.org/0000-0003-1451-9578 Department of Medical Biology, Molecular Cancer Research Group, University of Tromsø—The Arctic University of Norway, Tromsø, Norway Search for more papers by this author Gábor Juhász Gábor Juhász Institute of Genetics, Biological Research Center, Szeged, Hungary Department of Anatomy, Cell and Developmental Biology, Eötvös Loránd University, Budapest, Hungary Search for more papers by this author Vassiliki Karantza Vassiliki Karantza Merck & Co., Inc., Kenilworth, NJ, USA Search for more papers by this author Claudine Kraft Claudine Kraft orcid.org/0000-0002-3324-4701 Institute of Biochemistry and Molecular Biology, ZBMZ, Faculty of Medicine, University of Freiburg, Freiburg, Germany CIBSS - Centre for Integrative Biological Signalling Studies, University of Freiburg, Freiburg, Germany Search for more papers by this author Guido Kroemer Guido Kroemer orcid.org/0000-0002-9334-4405 Centre de Recherche des Cordeliers, Equipe Labellisée par la Ligue Contre le Cancer, Université de Paris, Sorbonne Université, Inserm U1138, Institut Universitaire de France, Paris, France Metabolomics and Cell Biology Platforms, Institut Gustave Roussy, Villejuif, France Pôle de Biologie, Hôpital Européen Georges Pompidou, AP-HP, Paris, France Suzhou Institute for Systems Medicine, Chinese Academy of Medical Sciences, Suzhou, China Karolinska Institute, Department of Women's and Children's Health, Karolinska University Hospital, Stockholm, Sweden Search for more papers by this author Nicholas T Ktistakis Nicholas T Ktistakis Signalling Programme, Babraham Institute, Cambridge, UK Search for more papers by this author Sharad Kumar Sharad Kumar orcid.org/0000-0001-7126-9814 Centre for Cancer Biology, University of South Australia, Adelaide, SA, Australia Faculty of Health and Medical Sciences, University of Adelaide, Adelaide, SA, Australia Search for more papers by this author Carlos Lopez-Otin Carlos Lopez-Otin orcid.org/0000-0001-6964-1904 Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Instituto Universitario de Oncología del Principado de Asturias (IUOPA), Universidad de Oviedo, Oviedo, Spain Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain Search for more papers by this author Kay F Macleod Kay F Macleod The Ben May Department for Cancer Research, The Gordon Center for Integrative Sciences, W-338, The University of Chicago, Chicago, IL, USA The University of Chicago, Chicago, IL, USA Search for more papers by this author Frank Madeo Frank Madeo Institute of Molecular Biosciences, NAWI Graz, University of Graz, Graz, Austria BioTechMed-Graz, Graz, Austria Field of Excellence BioHealth – University of Graz, Graz, Austria Search for more papers by this author Jennifer Martinez Jennifer Martinez Immunity, Inflammation and Disease Laboratory, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC, USA Search for more papers by this author Alicia Meléndez Alicia Meléndez Biology Department, Queens College, City University of New York, Flushing, NY, USA The Graduate Center Biology and Biochemistry PhD Programs of the City University of New York, New York, NY, USA Search for more papers by this author Noboru Mizushima Noboru Mizushima orcid.org/0000-0002-6258-6444 Department of Biochemistry and Molecular Biology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan Search for more papers by this author Christian Münz Christian Münz orcid.org/0000-0001-6419-1940 Viral Immunobiology, Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland Search for more papers by this author Josef M Penninger Josef M Penninger Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA), Vienna BioCenter (VBC), Vienna, Austria Department of Medical Genetics, Life Sciences Institute, University of British Columbia, Vancouver, BC, Canada Search for more papers by this author Rushika M Perera Rushika M Perera orcid.org/0000-0003-2435-2273 Department of Anatomy, University of California, San Francisco, San Francisco, CA, USA Department of Pathology, University of California, San Francisco, San Francisco, CA, USA Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, USA Search for more papers by this author Mauro Piacentini Mauro Piacentini orcid.org/0000-0003-2919-1296 Department of Biology, University of Rome “Tor Vergata”, Rome, Italy Laboratory of Molecular Medicine, Institute of Cytology Russian Academy of Science, Saint Petersburg, Russia Search for more papers by this author Fulvio Reggiori Fulvio Reggiori orcid.org/0000-0003-2652-2686 Department of Biomedical Sciences of Cells & Systems, Molecular Cell Biology Section, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands Search for more papers by this author David C Rubinsztein David C Rubinsztein Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK UK Dementia Research Institute, University of Cambridge, Cambridge, UK Search for more papers by this author Kevin M Ryan Kevin M Ryan Cancer Research UK Beatson Institute, Glasgow, UK Institute of Cancer Sciences, University of Glasgow, Glasgow, UK Search for more papers by this author Junichi Sadoshima Junichi Sadoshima Department of Cell Biology and Molecular Medicine, Cardiovascular Research Institute, Rutgers New Jersey Medical School, Newark, NJ, USA Search for more papers by this author Laura Santambrogio Laura Santambrogio Department of Radiation Oncology, Weill Cornell Medical College, New York, NY, USA Sandra and Edward Meyer Cancer Center, New York, NY, USA Caryl and Israel Englander Institute for Precision Medicine, New York, NY, USA Search for more papers by this author Luca Scorrano Luca Scorrano orcid.org/0000-0002-8515-8928 Istituto Veneto di Medicina Molecolare, Padova, Italy Department of Biology, University of Padova, Padova, Italy Search for more papers by this author Hans-Uwe Simon Hans-Uwe Simon Institute of Pharmacology, University of Bern, Bern, Switzerland Department of Clinical Immunology and Allergology, Sechenov University, Moscow, Russia Laboratory of Molecular Immunology, Institute of Fundamental Medicine and Biology, Kazan Federal University, Kazan, Russia Search for more papers by this author Anna Katharina Simon Anna Katharina Simon The Kennedy Institute of Rheumatology, NDORMS, University of Oxford, Oxford, UK Search for more papers by this author Anne Simonsen Anne Simonsen orcid.org/0000-0003-4711-7057 Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway Centre for Cancer Cell Reprogramming, Institute of Clinical Medicine, University of Oslo, Oslo, Norway Department of Molecular Cell Biology, Institute for Cancer Research, Oslo University Hospital Montebello, Oslo, Norway Search for more papers by this author Alexandra Stolz Alexandra Stolz orcid.org/0000-0002-3340-439X Institute of Biochemistry II, School of Medicine, Goethe University, Frankfurt, Frankfurt am Main, Germany Buchmann Institute for Molecular Life Sciences, Goethe University, Frankfurt, Frankfurt am Main, Germany Search for more papers by this author Nektarios Tavernarakis Nektarios Tavernarakis orcid.org/0000-0002-5253-1466 Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas, Heraklion, Crete, Greece Department of Basic Sciences, School of Medicine, University of Crete, Heraklion, Crete, Greece Search for mor