粘液
生物膜
幽门螺杆菌
褐藻糖胶
抗生素
声动力疗法
体内
活性氧
化学
微生物学
医学
细菌
生物
生物化学
多糖
生态学
生物技术
遗传学
内科学
作者
Jinjie Fan,Yuze Dong,Yue Sun,Yalan Ji,Jie Feng,Peijuan Yan,Yingnan Zhu
标识
DOI:10.1002/adhm.202400363
摘要
Abstract Helicobacter pylori ( H. pylori ) infection is closely associated with the development of various gastric diseases. The effectiveness of current clinical antibiotic therapy is hampered by the rise of drug‐resistant strains and the formation of H. pylori biofilm. This paper reports a sonodynamic nanocomposite PtCu 3 ‐PDA@AIPH@Fucoidan (PPAF), which consists of dopamine‐modified inorganic sonosensitizers PtCu 3 , alkyl radicals (R•) generator AIPH and fucoidan, can penetrate the mucus layer, target H. pylori , disrupt biofilms, and exhibit excellent bactericidal ability. In vitro experiments demonstrate that PPAF exhibits excellent acoustic kinetic properties, generating a significant amount of reactive oxygen species and oxygen‐independent R• for sterilization under ultrasound stimulation. Simultaneously, the produced N 2 can enhance the cavitation effect, aiding PPAF nanoparticles in penetrating the gastric mucus layer and disrupting biofilm integrity. This disruption allows more PPAF nanoparticles to bind to biofilm bacteria, facilitating the eradication of H. pylori . In vivo experiments demonstrate that ultrasound‐stimulated PPAF exhibited significant antibacterial efficacy against H. pylori . Moreover, it effectively modulated the expression levels of inflammatory factors and maintained gastrointestinal microbiota stability when compared to the antibiotic treatment group. In summary, PPAF nanoparticles present a potential alternative to antibiotics, offering an effective and healthy option for treating H. pylori infection.
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