免疫学
树突状细胞
免疫系统
炎症
细胞生物学
受体
周边公差
分泌物
医学
生物
T细胞
内科学
作者
Lucille Lamendour,Mäelle Gilotin,Nora Deluce-Kakwata Nkor,Zineb Lakhrif,Daniel Meley,Anne Poupon,Thibaut Laboute,Anne Di Tommaso,Jean‐Jacques Pin,Denis Mulleman,Guillaume Le Mélédo,Nicolas Aubrey,Hervé Watier,Florence Velge‐Roussel
标识
DOI:10.3389/fimmu.2024.1369117
摘要
There is an urgent need for alternative therapies targeting human dendritic cells (DCs) that could reverse inflammatory syndromes in many autoimmune and inflammatory diseases and organ transplantations. Here, we describe a bispecific antibody (bsAb) strategy tethering two pathogen-recognition receptors at the surface of human DCs. This cross-linking switches DCs into a tolerant profile able to induce regulatory T-cell differentiation. The bsAbs, not parental Abs, induced interleukin 10 and transforming growth factor β1 secretion in monocyte-derived DCs and human peripheral blood mononuclear cells. In addition, they induced interleukin 10 secretion by synovial fluid cells in rheumatoid arthritis and gout patients. This concept of bsAb-induced tethering of surface pathogen-recognition receptors switching cell properties opens a new therapeutic avenue for controlling inflammation and restoring immune tolerance.
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